Relation of fish oil supplementation to markers of atherothrombotic risk in patients with cardiovascular disease not receiving lipid-lowering therapy

The American Journal of Cardiology
Christopher J FranzesePaul A Gurbel

Abstract

Fish oil supplementation (FOS) is known to have cardiovascular benefits. However, the effects of FOS on thrombosis are incompletely understood. We sought to determine if the use of FOS is associated with lower indices of atherothrombotic risk in patients with suspected coronary artery disease (sCAD). This is a subgroup analysis of consecutive patients with sCAD (n=600) enrolled in the Multi-Analyte, Thrombogenic, and Genetic Markers of Atherosclerosis study. Patients on FOS were compared with patients not on FOS. Lipid profile was determined by vertical density gradient ultracentrifugation (n=520), eicosapentaenoic acid+docosahexaenoic acid was measured by gas chromatography (n=437), and AtherOx testing was performed by immunoassay (n=343). Thromboelastography (n=419), ADP- and collagen-induced platelet aggregation (n=137), and urinary 11-dehydrothromboxane B2 levels (n=259) were performed immediately before elective coronary angiography. In the total population, FOS was associated with higher eicosapentaenoic acid+docosahexaenoic acid content (p<0.001), lower triglycerides (p=0.04), total very low-density lipoprotein cholesterol (p=0.002), intermediate-density lipoprotein cholesterol (p=0.02), and AtherOx levels (p=0.02) but n...Continue Reading

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Citations

Jul 1, 2016·Future Medicinal Chemistry·Joe We Moss, Dipak P Ramji
Jul 8, 2016·Nature Reviews. Cardiology·Joe W E Moss, Dipak P Ramji
Oct 11, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Rahul ChaudharyPaul A Gurbel
Dec 20, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Michele ApSimon
Nov 8, 2018·Nutrients·Rosa CasasEmilio Sacanella
May 10, 2019·Frontiers in Immunology·Ana María Ruiz-LeónRosa Casas
May 8, 2021·Frontiers in Bioengineering and Biotechnology·Taotao WeiXueya Guo

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