PMID: 9536214Jun 1, 1997Paper

Relation of functional ovarian hyperandrogenism to non-insulin dependent diabetes mellitus

Baillière's Clinical Obstetrics and Gynaecology
David A Ehrmann

Abstract

Up to 40% of women with polycystic ovary syndrome (PCOS) demonstrate some degree of glucose intolerance, either impaired glucose tolerance (IGT) or non-insulin dependent diabetes mellitus (NIDDM). Defects in insulin action have long-been recognized as characteristic in these women. Recently, evidence has been obtained which documents that insulin secretory dysfunction also contributes significantly to the observed glucose intolerance. This chapter will focus on the recent evidence supporting the specific roles of disordered insulin secretion and action, in the development of glucose intolerance in PCOS. In addition, the use of pharmacological agents that modify insulin action as therapeutic options for women with PCOS, will be discussed.

References

Feb 1, 1991·The Journal of Clinical Investigation·J SturisK S Polonsky
Feb 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·C JohnstonD Porte
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·R W BergstromW Y Fujimoto
May 12, 1988·The New England Journal of Medicine·S O'RahillyD R Matthews
May 12, 1988·The New England Journal of Medicine·K S PolonskyE Van Cauter
Sep 1, 1987·The Journal of Clinical Endocrinology and Metabolism·A DunaifA Dobrjansky
Dec 1, 1967·The Journal of Clinical Investigation·M J Perley, D M Kipnis
Apr 1, 1982·The Journal of Clinical Endocrinology and Metabolism·B C HansenR A Wolfe
May 28, 1993·Annals of the New York Academy of Sciences·A Dunaif
May 1, 1993·The Journal of Clinical Endocrinology and Metabolism·N M O'MearaK S Polonsky
Mar 1, 1997·Diabetologia·D R McCanceW C Knowler

❮ Previous
Next ❯

Citations

Sep 15, 2004·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Aug 12, 2003·Fertility and Sterility·Mark O Goodarzi, Stanley G Korenman
Jun 3, 1999·Endocrinology and Metabolism Clinics of North America·D A Ehrmann
Dec 18, 1998·Journal of Endocrinological Investigation·D A Ehrmann
Jul 20, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·D Siassakos, P Wardle
Jun 28, 2002·Diabetes Care·Jana VrbíkováLuboslav Stárka
Aug 9, 2005·Endocrinology and Metabolism Clinics of North America·Colleen Buggs, Robert L Rosenfield
Dec 16, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·C J KellyH Lyall
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·David A EhrmannNancy J Cox
Jul 13, 2006·British Journal of Nursing : BJN·Maggi Banning
Nov 26, 2008·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.