Relation of heart rate recovery after exercise to insulin resistance and chronic inflammation in otherwise healthy adolescents and adults: results from the National Health and Nutrition Examination Survey (NHANES) 1999-2004

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Hsu-Ko Kuo, Joel M Gore

Abstract

Insulin resistance (IR) and chronic inflammation are inversely related to heart rate recovery (HRR), a marker of cardiac autonomic function. Little is known, however, about the joint effects of IR and inflammation on HRR. The study sample consisted of 2649 healthy individuals aged 12-49 years with measures of submaximal cardiopulmonary fitness testing from the National Health and Nutrition Examination Survey 1999-2004. HRR 1-min (HRR1) and 2-min (HRR2) after recovery were recorded (bpm). IR was defined if homeostasis model assessment (HOMA-IR) was ≥ 2.73. C-reactive protein (CRP) was quantified by latex-enhanced nephelometry. In the fully adjusted model, participants with IR had attenuated HRR compared to those without (mean HRR1 11.8 vs. 12.7, p = 0.011; mean HRR2 31.2 vs. 33.4, p < 0.001). Mean HRR1 for participants with CRP >0.3 mg/dL, CRP 0.1-0.3 mg/dL, and CRP <0.1 mg/dL were 11.6, 12.0, and 12.8 (p for trend 0.002), respectively. Mean HRR2 in the three corresponding groups were 33.0, 32.5, and 31.8 (p for trend 0.033), respectively. Participants with IR and CRP elevation had slower HRR than those without IR and with normal CRP. The mean HRR1 comparing participants with IR/CRP >0.3 mg/dL to those with no IR/CRP <0.1 mg/dL ...Continue Reading

References

Jul 1, 1979·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C T KappagodaJ P Newell
Oct 28, 1999·The New England Journal of Medicine·C R ColeM S Lauer
Sep 6, 2003·Journal of the American College of Cardiology·Deepak P VivekananthanMichael S Lauer
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
Aug 8, 2006·Journal of Korean Medical Science·Jidong SungJeong Bae Park
Jan 27, 2007·Atherosclerosis·Anne E Sumner, Catherine C Cowie
Feb 24, 2007·The American Journal of Cardiology·Sae Young JaeBo Fernhall
May 12, 2007·Journal of the American Geriatrics Society·Victoria J VieiraJeffrey A Woods
Oct 15, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Abdoulaye BaYves Jammes
Jun 30, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ergun Baris KayaAli Oto
Nov 9, 2011·Expert Review of Cardiovascular Therapy·Sercan OkutucuAli Oto
Apr 25, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Hikmet YorgunLale Tokgözoğlu
Jun 8, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·J W SacreT H Marwick

❮ Previous
Next ❯

Citations

Feb 6, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Sara RadenovicHans-Dirk Düngen
May 20, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Tatjana JezdimirovicSergej M Ostojic
Sep 26, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·S H QiuU Schumann
Mar 20, 2020·Andrologia·Yaşar Turan, Abdullah Gürel
Jan 13, 2019·European Journal of Applied Physiology·Kristin HaraldsdottirMarlowe W Eldridge
Nov 11, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wael AlJaroudi
May 16, 2021·Journal of Cardiopulmonary Rehabilitation and Prevention·Ross ArenaLeonard A Kaminsky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.