Abstract
Hyperthyroidism has a well-described association with atrial fibrillation (AF). However, the relation of hypothyroidism to AF has had limited investigation. Hypothyroidism is associated with cardiovascular risk factors, subclinical cardiovascular disease, and overt cardiovascular disease, all of which predispose to AF. We investigated 10-year incidence of AF in a community-dwelling cohort. Among 6,653 Framingham heart Study participants, 5,069 participants, 52% female, with mean age of 57 ± 12 years, were eligible after excluding those with missing thyroid-stimulating hormone (TSH), TSH <0.45 μU/L (hyperthyroid), TSH >19.9 μU/L, or prevalent AF. Thyroid-stimulating hormone was categorized by range (≥0.45 to <4.5, 4.5 to <10.0, 10.0 to ≤19.9 μU/L) and by quartiles. We examined the associations between TSH and 10-year risk of AF using multivariable-adjusted Cox proportional hazards analysis. Over 10-year follow-up, we observed 277 cases of incident AF. A 1-SD increase in TSH was not associated with increased risk of AF (hazard ratio 1.01, 95% CI 0.90-1.14, P = .83). In categorical analysis, using TSH ≥0.45 to <4.5 μU/L as the referent (equivalent to euthyroid state), we found no significant association between hypothyroidism and ...Continue Reading
References
Jan 1, 1979·Circulation·W B Kannel, D L McGee
Nov 10, 1994·The New England Journal of Medicine·C T SawinR B D'Agostino
Mar 16, 1994·JAMA : the Journal of the American Medical Association·E J BenjaminP A Wolf
Feb 19, 2000·Annals of Internal Medicine·A E HakJ C Witteman
Dec 12, 2001·Circulation·M K ChungD R Van Wagoner
Nov 19, 2003·Circulation·Ronnier J AvilesMina K Chung
Mar 1, 1951·American Journal of Public Health and the Nation's Health·T R DAWBERF E MOORE
Aug 2, 2005·Thyroid : Official Journal of the American Thyroid Association·Moffat J NyirendaAnthony D Toft
Mar 2, 2006·JAMA : the Journal of the American Medical Association·Anne R CappolaPaul W Ladenson
Apr 7, 2007·Journal of Hypertension·Vasilios KotsisNikos Zakopoulos
Mar 4, 2008·Journal of Clinical Epidemiology·Erik von ElmUNKNOWN STROBE Initiative
Oct 15, 2009·Endocrine·Yu DuanChao Liu
Sep 23, 2010·JAMA : the Journal of the American Medical Association·Nicolas RodondiUNKNOWN Thyroid Studies Collaboration
Apr 28, 2011·Clinical Endocrinology·Anders SvareArnulf Langhammer
Jan 13, 2012·The Journal of Clinical Endocrinology and Metabolism·David NanchenUNKNOWN PROSPER Group
Apr 25, 2012·Archives of Internal Medicine·Tinh-Hai ColletUNKNOWN Thyroid Studies Collaboration
Jul 24, 2012·Circulation·Baris GencerUNKNOWN Thyroid Studies Collaboration
Nov 29, 2012·BMJ : British Medical Journal·Christian SelmerGunnar Hilmar Gislason
Citations
Mar 13, 2016·Heart Failure Clinics·Patrick Dillon, Hamid Ghanbari
Jul 6, 2014·Herz·S MarrakchiS Kachboura
Dec 11, 2014·Current Heart Failure Reports·Viswanathan Rajagopalan, A Martin Gerdes
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Nov 4, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paulus KirchhofKatja Zeppenfeld
Sep 25, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Paulus KirchhofKatja Zeppenfeld
Nov 1, 2016·PloS One·Der-Yuan ChenHsin-Hua Chen
Jul 15, 2018·Journal of the American Heart Association·Itsuro MorishimaToyoaki Murohara
Nov 29, 2017·Circulation·Christian Selmer, Jens Faber
Oct 25, 2017·Circulation·Christine BaumgartnerUNKNOWN Thyroid Studies Collaboration
Jun 9, 2019·Endocrine·Jianqiang LiYue Li
Jul 26, 2017·Methodist DeBakey Cardiovascular Journal·Maja UdovcicAbhishek Kansara
Nov 9, 2017·Scientific Reports·Nan LuXuerui Tan
Feb 24, 2018·European Journal of Preventive Cardiology·Georgios MourtzinisKarin Manhem
May 26, 2018·Der Internist·U Dischinger, M Fassnacht
Nov 9, 2014·American Journal of Physiology. Heart and Circulatory Physiology·A Martin Gerdes
Mar 9, 2017·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Ki-Hun KimAndrea Natale
Mar 23, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Bulent GorenekUNKNOWN ESC Scientific Document Group
Feb 8, 2019·Frontiers in Neuroscience·Revathy CarnagarinMarkus P Schlaich
Nov 7, 2016·European Journal of Preventive Cardiology·Bulent Gorenek ChairAna Abreu
Oct 9, 2019·Current Cardiology Reviews·Negar OmidiParichehr Pasbakhsh
Oct 7, 2020·American Heart Journal·Inna Y GongLorraine L Lipscombe
Jul 21, 2020·Medicina clínica·Meng-Ya DongUNKNOWN CCC investigators