Relation of inflammatory markers with symptoms of psychotic disorders: a large cohort study

Progress in Neuro-psychopharmacology & Biological Psychiatry
E J LiemburgH Knegtering

Abstract

Immunological mechanisms may play a role in symptomatology of patients with a psychotic disorder. Besides metabolic problems and medication use, inflammatory processes that may occur due to the disorder may cause increased inflammatory markers and concurrent psychiatric symptoms. The aim of this study is to investigate whether levels of C-reactive protein (CRP) and white blood cell count (WBC) are related to positive and negative symptoms of psychotic disorders, and whether age, gender, duration of illness, smoking behavior, haloperidol equivalents, mediation use, body mass, and metabolic syndrome affect this relation. CRP and WBC values of 2123 patients with a psychotic disorder were related to positive and negative symptoms measured with a psychiatric interview. CRP was analyzed by survival analysis accounting for detection limit and WBC by linear mixed model analysis. In case of a significant association, the confounding factors were added to the model. Both WBC and CRP were related to both positive and negative symptoms, even after correction for age, gender, smoking, use of medication and metabolic problems. Of the covariates, gender, metabolic problems, smoking and statins also showed a strong association with inflammator...Continue Reading

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Oct 15, 1996·American Journal of Epidemiology·J SunyerJ M Samet
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adrienne C LahtiRobert McMahon
Apr 3, 2010·The American Journal of Psychiatry·David M GardnerRoss J Baldessarini
Jun 29, 2010·Schizophrenia Research·Francisco J DiazBenedicto Crespo-Facorro
May 31, 2011·Psychiatry Research·Mounir H FawziNagwa S Said
Jul 30, 2011·Psychiatry Research·Jaana SuvisaariAntti Jula
Sep 16, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ebrahim HaroonAndrew H Miller
Oct 4, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·A Sicras-MainarM Blanca-Tamayo
May 23, 2012·Tobacco Induced Diseases·José Antonio Fiz FernándezJosé Antonio Gelpi Méndez
Jul 17, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kyoung-Sae NaChul-Eung Kim
Oct 16, 2012·Biological Psychiatry·Brian J MillerAndrew Mellor
Dec 12, 2012·Schizophrenia Research·Faith DickersonRobert Yolken
Feb 23, 2013·Clinical Schizophrenia & Related Psychoses·Brian J MillerMark H Rapaport
May 21, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adrian L Lopresti, Peter D Drummond
Feb 22, 2014·Neuroimmunomodulation·Zuzanna Zajkowska, Valeria Mondelli
Feb 26, 2014·Psychiatry Research·Bisu Singh, Tapas Kumar Chaudhuri
Jun 17, 2014·Psychiatry Research·Elina A StefanovicsRobert A Rosenheck
Jun 4, 2015·Psychopharmacology·Golam M Khandaker, Robert Dantzer
Sep 7, 2016·Schizophrenia Research·Mari NerhusIngrid Melle
Nov 3, 2017·JAMA Psychiatry·Fernando Pires HartwigGeorge Davey Smith

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Citations

Mar 11, 2020·Frontiers in Psychiatry·David R Goldsmith, Mark Hyman Rapaport
Jul 7, 2020·Frontiers in Psychiatry·Emily G SeveranceRobert H Yolken
Feb 2, 2021·Psychiatry Research·Federica KlausStefan Kaiser
Jul 31, 2021·World Journal of Psychiatry·Matej ĽuptákJana Hroudová
Jan 8, 2022·Harvard Review of Psychiatry·David S Thylur, David R Goldsmith
Jan 18, 2022·European Archives of Psychiatry and Clinical Neuroscience·Meijuan LiJie Li

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