Relation of left ventricular midwall function to cardiovascular risk factors and arterial structure and function

Hypertension
R B DevereuxM J Roman

Abstract

Left ventricular (LV) midwall shortening (MWS) is subnormal in relation to LV circumferential end-systolic stress (ESS) (ESS-corrected MWS) in many hypertensive patients with normal LV chamber function and predicts subsequent morbidity and mortality. However, little is known of the relations of LV midwall function to demographic and metabolic variables or to arterial geometry. Asymptomatic, unmedicated normotensive (n=366) or hypertensive (n=282) adults were assessed with echocardiography and carotid ultrasound. In normal adults, lower LV MWS and ESS-corrected MWS, an index of LV contractility, were related independently to high total peripheral resistance, high heart rate, and male gender (all P<.00001), lower serum HDL cholesterol (P=.001) and diastolic pressure (P=.003), and for ESS-corrected MWS only, arterial relative wall thickness (RWT, P=.03). Among hypertensive patients, lower values for both midwall function indices were associated independently with higher peripheral resistance (P<.00001), heart rate (P<.00005), body mass index (P<.01), and arterial RWT (P=.04), as well as male gender (P<.0002). In the entire population, lower LV MWS was independently related to higher peripheral resistance, heart rate (both P<.00001...Continue Reading

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References

Jun 1, 1992·Journal of the American College of Cardiology·A GanauJ H Laragh
May 1, 1992·Hypertension·P L SchnallT G Pickering
Feb 1, 1991·Annals of Internal Medicine·G de SimoneJ H Laragh
Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R SalonenJ T Salonen
Jan 1, 1983·The American Journal of Cardiology·R B DevereuxJ H Laragh
Jan 1, 1995·Journal of the American College of Cardiology·M J RomanR B Devereux
Sep 1, 1996·Journal of the American College of Cardiology·M J RomanR B Devereux
Feb 1, 1996·The American Journal of Physiology·G De SimoneJ H Laragh

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Citations

Dec 13, 2006·Journal of Inherited Metabolic Disease·J S ShahP M Elliott
Sep 12, 2000·Current Hypertension Reports·D K Arnett
Sep 29, 2000·The American Journal of Cardiology·G SchillaciC Porcellati
Jun 12, 2003·Journal of the American College of Cardiology·Jennifer E LiuRichard B Devereux
Apr 10, 2003·Annals of Epidemiology·Richard B DevereuxBarbara V Howard
Jun 2, 2006·Journal of Human Hypertension·M Przewlocka-KosmalaW Mazurek
Jun 21, 2001·The Journal of Clinical Hypertension·J F Setaro
Nov 22, 2012·Cardiovascular Ultrasound·Hisao YoshikawaKaoru Sugi
Jul 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuo MurakamiJitsuo Higaki
Jun 6, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yinong JiangXiaohong Tian
Apr 13, 2004·Journal of Hypertension·Jonathan N BellaRichard B Devereux
Feb 11, 2005·Clinical and Experimental Hypertension : CHE·Enrico Agabiti Rosei, Maria Lorenza Muiesan
Oct 1, 2013·Metabolism: Clinical and Experimental·Adam T Whaley-ConnellJames R Sowers
Jan 16, 2009·International Journal of Cardiology·Piercarlo BalloSergio Mondillo
Mar 3, 2009·American Heart Journal·David AguilarCraig L Hanis
Mar 14, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G P NovelliH Valensise
Dec 28, 2004·The American Journal of Cardiology·Michael H OlsenUNKNOWN LIFE substudy
Jun 10, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Hae Ok JungCatherine M Otto
Sep 5, 2006·The American Journal of Cardiology·Jonathan N BellaRichard B Devereux
Feb 13, 2001·The American Journal of Cardiology·A CelentanoG de Simone
Jan 11, 2011·Korean Circulation Journal·Kyungil ParkYoung-Bae Park

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