Relation of left ventricular systolic dyssynchrony in patients with heart failure to left ventricular ejection fraction and to QRS duration

The American Journal of Cardiology
Chin-Pang ChanCheuk-Man Yu

Abstract

Left ventricular (LV) systolic dyssynchrony is an important pathologic mechanism in patients with heart failure (HF). However, the prevalence of intraventricular dyssynchrony in patients with different LV ejection fractions (EFs) is unknown. This study evaluated 402 consecutive patients with HF (mean age 64.99 +/- 13.15 years, 72.4% men) and 120 healthy controls. Dyssynchrony indexes included the SD of the time to peak systolic velocity (Ts) in ejection phase in the 12-segmental model (Ts-SD) and the difference in Ts between basal septal and basal lateral segments (Ts-Septal-Lateral) using tissue Doppler imaging. Patients were divided into 3 groups according to LVEF (LVEF <20%, >20% to 35%, and >35% to 50%) and compared with healthy controls. Both indexes were significantly higher in all 3 LVEF groups compared with controls (p <0.0001). Based on the established cut-off values, systolic dyssynchrony was equally prevalent in all 3 LVEF groups and was 67%, 62%, and 55% using Ts-SD and 38%, 36%, and 35% using Ts-Septal-Lateral, respectively. However, the prevalence of systolic dyssynchrony was higher using Ts-SD than Ts-Septal-Lateral (chi-square = 94.43, p <0.001). Conversely, the prevalence of electrical dyssynchrony, defined as ...Continue Reading

References

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Citations

Jan 27, 2012·European Heart Journal·Dominique AugerVictoria Delgado
Nov 26, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Paul W X FoleyFrancisco Leyva
Nov 11, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Francisco Leyva
Jul 13, 2013·Heart·Cheuk-Man Yu, Fang Fang
Dec 3, 2014·International Journal of Cardiology·Jing Ping SunCheuk-Man Yu
May 25, 2013·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Maria João Vidigal FerreiraLuís Augusto Providência
Mar 11, 2009·Pacing and Clinical Electrophysiology : PACE·Paul W X FoleyFrancisco Leyva
May 11, 2016·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Zsolt GyalaiDan Dobreanu

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