Relation of lipoprotein(a) as coronary risk factor to type 2 diabetes mellitus and low-density lipoprotein cholesterol in patients > or =65 years of age (The Italian Longitudinal Study on Aging)

The American Journal of Cardiology
V SolfrizziAntonio Capurso

Abstract

High levels of serum lipoprotein(a) [Lp(a)] have been associated with increased risk of coronary artery disease (CAD), but this association apparently is not confirmed in elderly people. We evaluated the interactions of Lp(a) with lipid and nonlipid CAD risk factors in a sample of subjects enrolled in the prevalence survey (1992 to 1993) of the Italian Longitudinal Study on Aging (ILSA). The entire population consisted of 5,632 elderly people, aged 65 to 84 years, randomly selected in 8 Italian municipalities. The present cross-sectional study included 400 free-living elderly subjects (74 +/- 6 years) from the randomized cohort of Casamassima (Bari, Southern Italy) (n = 704). The results showed that in the elderly population, high serum Lp(a) is a CAD risk factor dependent on type 2 diabetes mellitus and elevated low-density lipoprotein (LDL) cholesterol levels. In particular, the combined effect of high Lp(a) (> or =20 mg/dl) and high LDL cholesterol (> or =3.63 mmol/L [> or =140 mg/dl]), increases coronary risk by 2.75 (95% confidence interval 7.70 to 0.99); finally, the effect of Lp(a) > or =20 mg/dl and LDL cholesterol > or =3.63 mmol/L (> or =140 mg/dl), combined with type 2 diabetes mellitus, increases risk of CAD by 6.65...Continue Reading

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Citations

Mar 14, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Louise PiloteVicky Tagalakis
Feb 10, 2010·International Journal of Diabetes in Developing Countries·Seema SinglaShivani Jaswal
Jul 5, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Mehdi Rasouli, Asadollah Mohseni Kiasari
Mar 6, 2008·Dementia and Geriatric Cognitive Disorders·Francesco PanzaUNKNOWN Italian Longitudinal Study on Aging Working Group
Nov 10, 2007·Rejuvenation Research·Francesco PanzaVincenzo Solfrizzi
Dec 20, 2018·Expert Review of Clinical Pharmacology·Uffe RavnskovRalf Sundberg
Jun 15, 2007·Dementia and Geriatric Cognitive Disorders·Vincenzo SolfrizziUNKNOWN Italian Longitudinal Study on Aging Working Group
Jul 7, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Vincenzo SolfrizziUNKNOWN Italian Longitudinal Study on Aging Working Group
Jan 6, 2018·Expert Review of Clinical Pharmacology·Niki KatsikiDimitri P Mikhailidis
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Vincenzo SolfrizziUNKNOWN Italian Longitudinal Study on Aging Working Group
Jan 18, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Helmut Borberg
Jun 23, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Helmut Borberg

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