Relation of luteinizing hormone levels to body mass index in premenopausal women

Fertility and Sterility
K BohlkeR L Barbieri

Abstract

To assess the relationship between body mass index (BMI) and basal LH and the LH-FSH ratio in normally menstruating women. Cross-sectional analysis. A teaching hospital clinic. Premenopausal women without cancer, not currently using oral contraceptives, selected from a familial ovarian cancer clinic or the general population. None. Early follicular phase plasma LH and FSH. Luteinizing hormone increased slightly and nonsignificantly (P = 0.44) from the first to the second quintile of BMI and decreased over all subsequent quintiles. Women in the highest quintile of BMI (> 27.1) had significantly lower LH levels than women in the lowest quintile of BMI (< or = 20.4; P = 0.003). Compared with women in the second quintile of BMI who had the highest LH levels, women in the highest quintile of BMI had LH levels that were 40% lower. The relationship between BMI and the LH-FSH ratio was similar, though not as strong. Over most of the range of BMIs observed in this study, BMI was inversely associated with LH. These results suggest that the upper limits of normal for LH may need to be shifted downward for heavier women.

Citations

May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Annekatrin LukanovaRudolf Kaaks
Jun 23, 2000·Obstetrics and Gynecology·R EcochardH Boehringer
Apr 12, 2003·Obstetrics and Gynecology·Robert L Barbieri
Feb 9, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E H YeungE F Schisterman
Apr 11, 2001·Obstetrics and Gynecology Clinics of North America·V Lewis

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