Relation of matrix metalloproteinase-9 to different stages of tumors in the serum of gastric cancer.

Digestive Diseases and Sciences
V DragutinovićN Radovanović

Abstract

The sera of 40 patients with gastric cancer and 11 patients as the control group were studied for the detection of matrix metalloproteinases. The malignant behavior of tumor cells mainly depends on the capability of invasion and the metastasis of cancer cells. After the components of the extracellular matrix (ECM) are degraded, tumor cells invade the surrounding tissue and the vascular or lymphatic vessels to form metastasis colonies at distant sites. Extracellular proteolytic enzymes implicate the invasion and metastasis of cancer. Proteolytic enzymes from tumors lead to the breakdown of basement membranes and the ECM, thereby, facilitating cancer cell invasion into the surrounding normal tissue. Proteinase activity is overexpressed in the serum of stage 3 and 4 tumors compared to stage 1 and 2 tumors. ProMMP-9 was detected in the serum of patients of gastric cancer by SDS polyacrylamide gel electrophoresis (SDS-PAGE) and SDS-PAGE zymography, with its molecular mass of 92 kDa. MMP-9 in serum plays an important role in the progression of gastric cancer.

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Citations

May 2, 2009·BMC Gastroenterology·Kawin LeelawatJerasak Wannaprasert
Dec 1, 2009·Medicina clínica·Sol de la PeñaKenneth León-Córdoba
Jun 20, 2018·Endocrine-related Cancer·Sunmi ParkSheue-Yann Cheng
Jun 29, 2012·Oncology Letters·Sewon NohSun Young Rha
May 30, 2020·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Mohammad Reza AbbaszadeganMeysam Moghbeli
Aug 11, 2020·Clinical and Experimental Medicine·Nahla E El-AshmawyGhada M Al-Ashmawy
Aug 13, 2013·Experimental and Therapeutic Medicine·Min ZhaoZheng-Sheng Wu

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