Relation of Mitral Annulus and Left Atrial Dysfunction to the Severity of Functional Mitral Regurgitation in Patients with Dilated Cardiomyopathy

Cardiology Research and Practice
Sorina Mihaila BaldeaLuigi Paolo Badano

Abstract

56 patients (58 ± 17 years, 42 men) with DCM and FMR and 52 controls, prospectively enrolled, underwent 3DTTE dedicated for mitral valve (MV), LA, and left ventricle (LV) quantitative analysis. Patients with FMR vs. controls presented increased MA size and sphericity during the entire systole, whereas MA fractional area change (MAFAC) and MA displacement were decreased (15 ± 5 vs. 28 ± 5%; and 5 ± 3 vs. 10 ± 2 mm, p < 0.001). In patients with moderate/severe FMR, MA diameters correlated with PISA radius, EROA, and regurgitant volume (Rvol), as also did the MA area (with PISA radius, EROA, and Rvol: r = 0.48, r = 0.58, and r = 0.47, p < 0.05). MAFAC correlated inversely with EROA and Rvol (r = -0.32 and r = -0.35, p < 0.05), with both active and total LA emptying fractions and with LV ejection fraction as well. In a stepwise multivariate regression model, decreased MAFAC and increased LA volume independently predicted patients with severe FMR. Patients with DCM and FMR have MA geometry remodeling and contractile dysfunction, correlated with the severity of FMR. MA contractile dysfunction correlated with both LA and left LV pumps dysfunctions and predicted patients with severe FMR. Our results provide new insights that might help...Continue Reading

References

Oct 27, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jun KwanTakahiro Shiota
Nov 30, 2004·The American Journal of Cardiology·Patrizio LancellottiLuc A Piérard
Dec 20, 2005·Journal of the American College of Cardiology·Shota FukudaTakahiro Shiota
Jan 1, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Denisa MuraruAlessandro Proclemer
May 4, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Patrizio LancellottiUNKNOWN European Association of Echocardiography
Jul 28, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Stephen H LittleWilliam A Zoghbi
Sep 24, 2011·Journal of the American College of Cardiology·Zachary M GertzFrank E Silvestry
Apr 20, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Steven F Bolling
Aug 11, 2012·American Heart Journal·Jeffrey J Silbiger
Apr 25, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Denisa MuraruSabino Iliceto
Jun 4, 2013·Journal of the American Heart Association·Yan TopilskyMaurice Enriquez-Sarano
Aug 21, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jeffrey J Silbiger
Nov 20, 2013·The New England Journal of Medicine·Michael A AckerUNKNOWN CTSN
Jun 4, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sorina MihăilăLuigi P Badano
Oct 17, 2014·The International Journal of Cardiovascular Imaging·Sorina MihailaLuigi P Badano
Nov 5, 2014·European Heart Journal Cardiovascular Imaging·Philippe DebonnaireVictoria Delgado
May 20, 2015·Interactive Cardiovascular and Thoracic Surgery·Yosuke TakahashiToshihiko Shibata
Mar 14, 2016·JACC. Cardiovascular Imaging·Philipp BlankeJonathon Leipsic
Apr 5, 2016·The New England Journal of Medicine·Robert E MichlerUNKNOWN CTSN
Aug 31, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Marina UrenaLars Søndergaard
May 16, 2019·The New England Journal of Medicine·Dimitri KalavrouziotisSiamak Mohammadi
May 16, 2019·The New England Journal of Medicine·Gregg W StoneUNKNOWN COAPT Investigators

❮ Previous
Next ❯

Methods Mentioned

BETA
PISA

Software Mentioned

MedCalc
TOMTEC
SPSS
3DTTE

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.