Relation of nonalcoholic fatty liver disease and Framingham Risk Score to flow-mediated dilation in patients with cardiometabolic risk factors

The American Journal of Cardiology
Daniele PastoriFrancesco Angelico

Abstract

Nonalcoholic fatty liver disease (NAFLD) has a high prevalence in the general population. Brachial artery flow-mediated dilation (FMD) is a surrogated marker of early atherosclerosis. Few data investigating the relation between FMD, NAFLD, and cardiovascular (CV) risk are available. We recruited 367 consecutive outpatients with cardiometabolic risk factors who underwent ultrasound scanning for liver steatosis and FMD. Mean age was 54.2 ± 12.2 years, and 37% were women. NAFLD was present in 281 patients (77%). Median FMD was 5.1%. FMD was significantly reduced in patients with NAFLD (p <0.001), diabetes (p = 0.001), history of coronary heart disease (p = 0.034), and metabolic syndrome (p = 0.050) and in those taking antihypertensive drugs (p = 0.022). Women disclosed greater FMD than males (p = 0.033). Moreover, FMD inversely correlated with age (Spearman rank correlation test [Rs], -0.171; p = 0.001), waist circumference (Rs, -0.127; p = 0.016), fasting blood glucose (Rs, -0.204; p <0.001), and gamma-glutamyl transpeptidase (Rs, -0.064; p = 0.234). At multivariate regression analysis, fasting blood glucose (β, -0.148; p = 0.008), age (β, -0.158; p = 0.005), and the presence of NAFLD (β, -0.132; p = 0.016) inversely correlated w...Continue Reading

References

May 29, 1998·Circulation·P W WilsonW B Kannel
Jun 28, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicola VillanovaGiulio Marchesini
Sep 15, 2006·Atherosclerosis·Giovanni Targher, Guido Arcaro
Jun 15, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P LoriaN Carulli
Apr 3, 2008·Internal Medicine Journal·R K Schindhelm, M Diamant
Mar 17, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A SciacquaF Perticone
May 13, 2010·Digestive Diseases·Stephen Caldwell, Curtis Argo
Oct 1, 2010·The New England Journal of Medicine·Giovanni TargherEnzo Bonora
Jan 25, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Donghee KimW Ray Kim
Oct 25, 2012·Internal and Emergency Medicine·Eugenio GaudioGuido Carpino
Dec 3, 2014·International Journal of Cardiology·Ludovica PerriLorenzo Loffredo

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Citations

Sep 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincent Wai-Sun WongHenry Lik-Yuen Chan
Nov 26, 2015·International Journal of Molecular Sciences·Francesco BarattaMaria Del Ben
Oct 2, 2015·Clinical and Translational Gastroenterology·Daniele PastoriFrancesco Angelico
Mar 8, 2017·BMC Gastroenterology·Marcello PersicoCarmine Vecchione
Jun 12, 2020·World Journal of Gastroenterology : WJG·Ilaria UmbroMaria Del Ben
Apr 29, 2016·World Journal of Gastroenterology : WJG·Hakan Fotbolcu, Elçin Zorlu
Feb 3, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Paula IruzubietaJavier Crespo

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