Relation of phosphodiesterase type 5 inhibitors and malignant melanoma: a meta-analysis and systematic review

Oncotarget
Jie WangKangting Ji

Abstract

Data on the association between using PDE5 inhibitors and malignant melanoma are conflicting. To estimate the relation of using PDE5 inhibitors with risk of malignant melanoma, Medline (Ovid) and Embase (Ovid) databases were searched up to February 2017, and a random effects model was used to calculate the summary risk estimates. Five observational studies were included. Five studies reports encompassed a total of 15,979 melanoma cases occurring among 1, 188,414 participants. The pooled multivariable-adjusted RR of melanoma in patients with using PDE5 inhibitors was 1.12 (95% CI: 1.03-1.21, I2 = 0.48). Findings from this systematic review support that PDE5 inhibitor use is associated with increased risk of melanoma in ED patients, the result remains inclusive and warrants further study in the future.

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Citations

Dec 13, 2017·Oncotarget·Ines BaroneStefania Catalano
Aug 23, 2019·Expert Opinion on Drug Safety·Murat Gul, Ege Can Serefoglu
Dec 13, 2017·BioMed Research International·Hua LiDepu Zhou
Nov 10, 2017·Scientific Reports·Lai Lai FanZhi Juan Dai
Mar 4, 2020·International Journal of Oncology·Romina Gabriela ArmandoDaniel Eduardo Gomez
Nov 28, 2018·The Cochrane Database of Systematic Reviews·Smita PattanaikArup K Mandal

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