Relation of plasma insulin levels to forearm flow-mediated dilatation in healthy volunteers

The American Journal of Cardiology
Diego ArdigòIvana Zavaroni

Abstract

Although several observations suggest that insulin resistance/compensatory hyperinsulinemia (IR/CH) has a direct effect on endothelial function, independently of the metabolic abnormalities associated with the defect in insulin action, this relation has not been evaluated in apparently healthy individuals. To address this issue, we measured endothelial-dependent vasodilation in response to forearm ischemia (flow-mediated dilation [FMD]) in 47 nonsmoking, healthy volunteers without known risk factors for atherosclerosis. Measurements were also made of multiple anthropometric, metabolic, and hemodynamic variables related to IR/CH. Decreases in FMD were significantly correlated (analysis of variance for linear trend) with (1) male gender (p = 0.003), (2) waist circumference (p = 0.038), (3) higher fasting plasma insulin (p = 0.015) and triglyceride concentrations (p = 0.023), and (4) lower concentrations of high-density lipoprotein cholesterol (p = 0.001). Multivariate linear regression analysis indicated that only plasma insulin (beta -0.424) was independently associated (p <0.001) with changes in FMD, and individual differences in insulin concentrations, along with gender and brachial artery diameter at baseline, accounted for a...Continue Reading

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Citations

Feb 27, 2010·Reviews in Endocrine & Metabolic Disorders·Corey E TabitJoseph A Vita
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Barbara A GowerFernando Ovalle
Mar 9, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Christopher G EllisRandy S Sprague
Jan 28, 2014·Metabolic Syndrome and Related Disorders·Paula R PienaarEstelle V Lambert
Apr 2, 2011·European Journal of Pharmacology·Lu-Lu ChenHong-cheng Ding
Aug 3, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L FranziniI Zavaroni
Mar 24, 2009·European Journal of Clinical Investigation·S BuscemiG Cerasola
Mar 22, 2007·European Journal of Clinical Investigation·D ArdigoI Zavaroni
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Mar 17, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A SciacquaF Perticone
Aug 28, 2013·Journal of the American College of Cardiology·Sherman J BigorniaNoyan Gokce
Sep 13, 2014·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Debashis NandyAnanda Basu
Jun 24, 2008·Expert Review of Cardiovascular Therapy·Stephen Fava
Feb 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Lusha XiangRobert L Hester
Apr 6, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Robert P HoffmanChack-Yung Yu

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