Relation of Prenatal Methylmercury Exposure from Environmental Sources to Childhood IQ

Environmental Health Perspectives
J L JacobsonS W Jacobson

Abstract

Although prenatal methylmercury exposure has been linked to poorer intellectual function in several studies, data from two major prospective, longitudinal studies yielded contradictory results. Associations with cognitive deficits were reported in a Faroe Islands cohort, but few were found in a study in the Seychelles Islands. It has been suggested that co-exposure to another contaminant, polychlorinated biphenyls (PCBs), may be responsible for the positive findings in the former study and that co-exposure to nutrients in methylmercury-contaminated fish may have obscured and/or protected against adverse effects in the latter. We aimed to determine the degree to which co-exposure to PCBs may account for the adverse effects of methylmercury and the degree to which co-exposure to docosahexaenoic acid (DHA) may obscure these effects in a sample of Inuit children in Arctic Québec. IQ was estimated in 282 school-age children from whom umbilical cord blood samples had been obtained and analyzed for mercury and other environmental exposures. Prenatal mercury exposure was related to poorer estimated IQ after adjustment for potential confounding variables. The entry of DHA into the model significantly strengthened the association with me...Continue Reading

References

Jan 1, 1991·Progress in Lipid Research·S M Innis
Aug 1, 1986·The Journal of Pediatrics·W J RoganM Tully
Aug 25, 1988·The New England Journal of Medicine·A J McMichaelR J Roberts
Sep 12, 1996·The New England Journal of Medicine·J L Jacobson, S W Jacobson
Dec 11, 1997·Neurotoxicology and Teratology·P GrandjeanP J Jørgensen
Apr 16, 1998·Environmental Health Perspectives·L G Hansen
Feb 11, 1999·Risk Analysis : an Official Publication of the Society for Risk Analysis·K S CrumpA Stewart
Jul 31, 1999·Environmental Health Perspectives·E Budtz-JørgensenR F White
Dec 19, 2001·Environmental Health Perspectives·G MuckleJ L Jacobson
Jan 8, 2003·Environmental Health Perspectives·Matthew P LongneckerAllan A Jensen
Apr 18, 2003·The New England Journal of Medicine·Richard L CanfieldBruce P Lanphear
Jul 5, 2003·Environmental Health Perspectives·Pierre AyotteUNKNOWN Inuit Cohort Study
Aug 26, 2003·Occupational and Environmental Medicine·B LévesqueE Dewailly
Sep 2, 2003·Environmental Health Perspectives·Alan H Stern, Andrew E Smith
Apr 29, 2004·Neurotoxicology and Teratology·Lisa M ChiodoJoseph L Jacobson
Jul 21, 2004·Child Development·John ColomboSusan E Carlson
Jul 9, 2005·Environmental Health Perspectives·Bruce P LanphearRussell Roberts
Oct 6, 2005·Environmental Health Perspectives·Emily OkenMatthew W Gillman
May 6, 2006·Environmental Health Perspectives·Lourdes SchnaasEstela Perroni
Oct 28, 2006·Neurotoxicology and Teratology·Frodi DebesPhilippe Grandjean
Apr 14, 2007·Environmental Health Perspectives·Esben Budtz-JørgensenPal Weihe
Sep 15, 2007·Environmental Research·Anna L ChoiPhilippe Grandjean
Aug 19, 2008·Environmental Health Perspectives·Sally Ann LedermanFrederica P Perera
Oct 23, 2008·Environmental Health Perspectives·Paul W StewartThomas Darvill
Aug 20, 2014·The Science of the Total Environment·M LemireE Dewailly

❮ Previous
Next ❯

Citations

Sep 2, 2015·ILAR Journal·Kun LuJames G Fox
Jun 7, 2016·International Journal of Hygiene and Environmental Health·Rejane C MarquesJosé G Dórea
Jun 23, 2016·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Olivier BoucherJoseph L Jacobson
Aug 31, 2016·Environment International·Olivier BoucherJoseph L Jacobson
Nov 9, 2016·Neurotoxicology·Djai B Heyer, Rhiannon M Meredith
Oct 2, 2015·PloS One·Catherine McLean PirklePhilippe Max Rouja
Jul 22, 2018·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Thérèse Yéro AdamouPierre Ayotte
Oct 14, 2017·Epidemiology·Reiko KishiSumal Nandasena
Apr 29, 2020·Bulletin of Environmental Contamination and Toxicology·Stephani Ferreira da SilvaMarcelo de Oliveira Lima
Oct 17, 2018·Stochastic Environmental Research and Risk Assessment : Research Journal·Li-Shan HuangPhilip W Davidson
Jan 10, 2018·Archives of Environmental Contamination and Toxicology·Emiko KusanagiNobuko Hoshi
Aug 12, 2020·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·David A McVeaTom Kosatsky
May 28, 2020·Public Health Nutrition·Maude Bradette-LaplanteGina Muckle
Dec 16, 2016·International Journal of Circumpolar Health·Pál WeiheEva Bonefeld-Jørgensen
Nov 10, 2016·International Journal of Environmental Research and Public Health·Jenny L CarwileAnn Aschengrau
Jun 27, 2019·Journal of Exposure Science & Environmental Epidemiology·Catherine M BulkaRebecca C Fry
Oct 27, 2018·Marine Drugs·Ana R CircuncisãoArtur M S Silva
Jul 20, 2019·Environmental Health Insights·David Villar, David J Schaeffer
Nov 20, 2016·International Journal of Epidemiology·Sabrina LlopMaria-Jose Lopez-Espinosa
Dec 6, 2017·International Journal of Environmental Research and Public Health·Keith Schofield
Dec 24, 2020·Annals of Global Health·Philip J LandriganPatrick Rampal
Jun 9, 2020·Neurotoxicology and Teratology·Vickie Lamoureux-TremblayDave Saint-Amour
Mar 30, 2021·Current Epidemiology Reports·Julia A BauerBirgit Claus Henn
Feb 3, 2020·Chemosphere·Stephani Ferreira da Silva, Marcelo de Oliveira Lima
Jan 20, 2019·Biochimica Et Biophysica Acta. General Subjects·Pablo A NogaraJoão B T Rocha
Sep 4, 2019·Environmental Science & Technology·Aditya Kumar, Shiliang Wu
Jul 1, 2020·Ecotoxicology and Environmental Safety·Lin FengXinbin Feng
Jan 7, 2022·Chemical Research in Toxicology·Jingjing PanWei Liu

❮ Previous
Next ❯

Software Mentioned

BNT
VFT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.