Relation of reduced preclinical left ventricular diastolic function and cardiac remodeling in overweight youth to insulin resistance and inflammation

The American Journal of Cardiology
Rachana DahiyaGary M Leong

Abstract

Insulin resistance (IR) and inflammation are associated with an increased risk of cardiovascular disease and may contribute to obesity cardiomyopathy. The earliest sign of obesity cardiomyopathy is impaired left ventricular (LV) diastolic function, which may be evident in obese children and adolescents. However, the precise metabolic basis of the impaired LV diastolic function remains unknown. The aims of this study were to evaluate cardiac structure and LV diastolic function by tissue Doppler imaging in overweight and obese (OW) youth and to assess the relative individual contributions of adiposity, IR, and inflammation to alterations in cardiac structure and function. We studied 35 OW (body mass index standard deviation score 2.0±0.8; non-IR n=19, IR n=16) and 34 non-OW youth (body mass index standard deviation score 0.1±0.7). LV diastolic function was reduced in OW youth compared with non-OW controls, as indicated by lower peak myocardial relaxation velocities (p<0.001) and greater filling pressures (p<0.001). OW youth also had greater LV mass index (p<0.001), left atrial volume index, and LV interventricular septal thickness (LV-IVS; both p=0.02). IR-OW youth had the highest LV filling pressures, LV-IVS, and relative wall t...Continue Reading

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Citations

Oct 21, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Meltem AkcaboyNecla Buyan
Apr 7, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P Di BonitoUNKNOWN “CARdiometabolic risk factors in overweight and obese children in ITALY” (CARITALY) Study Group
May 12, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Linyuan JingBrandon K Fornwalt
Jul 6, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ju Young JungJoong-Myung Choi
Dec 24, 2018·Journal of Cardiovascular Electrophysiology·Naoko HijiokaYasuchika Takeishi
Jan 24, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Nádia GonçalvesAdelino F Leite-Moreira
Apr 5, 2021·The Journal of Pediatrics·Jareatha N Abdul-RaheemTammy M Brady
Aug 11, 2018·Journal of Molecular and Cellular Cardiology·Shih-Lin ChangShih-Ann Chen
May 6, 2021·Physiological Reviews·Jun RenYingmei Zhang

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