Relation of secretory phospholipase A(2) and high-sensitivity C-reactive protein to Chlamydia pneumoniae infection in acute coronary syndromes

Circulation Journal : Official Journal of the Japanese Circulation Society
Norio MiyaKatsuo Kanmatsuse

Abstract

Recently it has become clear that inflammatory changes play a part in the development of atherosclerosis, including coronary artery disease, and Chlamydia pneumoniae (C. pneumoniae) is thought to be a proinflammatory factor. The plasma concentration of high-sensitive C-reactive protein (hs-CRP) is a potential predictor of outcome in atherosclerotic diseases. Recent interest has focused on secretory group IIA phospholipase A(2) (sPLA (2)) in regard to the progression of atherosclerotic disease. The concentrations of sPLA(2), hs-CRP, and the titers of C. pneumoniae IgG and IgA antibodies were measured in blood samples. The study groups were an acute coronary syndrome (ACS) group, old myocardial infarction/angina pectoris (OMI/AP) group, and a control group. The concentrations of sPLA(2) and hs-CRP in the ACS group and the OMI/AP group were higher than in the control group. The titers of C. pneumoniae IgG and IgA were higher in the ACS group than in the control group. The sPLA(2) concentration was higher in those who were positive to C. pneumoniae IgG/IgA than in those who were negative. Increased concentrations of sPLA(2) reflect participation in the progression of coronary artery disease. The sPLA(2) concentration was higher in ...Continue Reading

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Citations

Jul 1, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Yukihiko MomiyamaFumitaka Ohsuzu
Jun 27, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Kuniaki JitsuikiNobuoki Kohno
Jun 27, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Chitose IshikawaMinoru Horie
Feb 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Navapun CharuruksMathuros Chaiworaporn
Dec 17, 2010·World Journal of Cardiology·Giovanni FazioSalvatore Novo

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