Relation of serum heat shock protein 60 level to severity and prognosis in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

The American Journal of Cardiology
Takeshi NiizekiIsao Kubota

Abstract

Heat shock protein (HSP) 60 is induced by a variety of stressors, including oxidative stress and inflammation, and it plays a protective role against stress-induced cardiomyocyte injury. Recently, it has been reported that HSP 60 exists in the circulation. Chronic heart failure (CHF) is characterized by systemic abnormalities, and the myocardium is exposed to various stressors. However, the clinical significance of serum HSP 60 has not been examined in CHF. Therefore, the purpose of this study was to examine whether HSP 60 is correlated with the severity of CHF and whether HSP 60 can predict clinical outcomes in patients with CHF. Serum HSP 60 levels were measured in 112 patients with CHF and 62 control subjects. Serum HSP 60 levels were higher in patients with CHF than in control subjects and increased with advancing New York Heart Association functional class. There were 37 cardiac events during a mean follow-up period of 569 +/- 476 days (range 17 to 1,986). Serum HSP 60 levels were higher in patients with cardiac events than in event-free patients. Patients were divided into 4 groups on the basis of HSP 60 level. Cox proportional-hazards regression analysis and Kaplan-Meier analysis revealed that the fourth quartile was ass...Continue Reading

References

Feb 12, 1998·Journal of Critical Care·G DeloguL Signore
May 29, 1998·Journal of Molecular and Cellular Cardiology·A A KnowltonD L Mann
Jan 24, 2002·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J GrünenfelderM Turina
Nov 20, 2002·Circulation·S Gupta, A A Knowlton
Jan 13, 2006·Kidney International·H TanakaK Iseki

❮ Previous
Next ❯

Citations

Jan 21, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ruth EisslerMarcus Baumann
Jan 28, 2014·PloS One·Kumar KotloRobert S Danziger
Jun 19, 2012·Congestive Heart Failure·Clara BonanadFrancisco J Chorro
Jun 6, 2019·Menopause : the Journal of the North American Menopause Society·Daniel de Araujo Brito ButtrosEliana A P Nahas
Aug 19, 2020·Medicinal Research Reviews·Indumathi Krishnan-SivadossC Enrique Guerrero-Beltrán
Aug 16, 2018·Pflügers Archiv : European journal of physiology·Larissa M DorschBianca J J M Brundel
Jul 3, 2020·Frontiers in Molecular Biosciences·Jonas Bernardes de Lima FilhoClaudio Lera Orsatti
Aug 28, 2019·Menopause : the Journal of the North American Menopause Society·Daniel de Araujo Brito ButtrosEliana A P Nahas
May 20, 2020·Frontiers in Molecular Biosciences·Yaoyun DuanKunfu Ouyang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis