Relation of serum uric acid to cardiovascular disease

International Journal of Cardiology
Audrey H WuGerasimos S Filippatos

Abstract

This review summarizes recent published literature on the association between serum uric acid and cardiovascular disease, a relationship which is complex and not fully elucidated. Uric acid may be a marker for risk, a causative agent in cardiovascular disease, or both. Various biologic factors can influence serum uric acid levels, and serum uric acid level itself is closely related to conditions such as hypertension, dyslipidemia, obesity, and impaired glucose metabolism, that contribute to cardiovascular disease pathophysiology. Serum uric acid levels have been found to be associated with adverse outcomes, including mortality, in the general population. In addition, serum uric acid is associated with increased risk for incident coronary heart disease, heart failure, and atrial fibrillation. In the setting of established systolic heart failure, serum uric acid is positively associated with disease severity and mortality risk. Whether targeting treatment based on uric acid levels might affect clinical outcomes is still being studied.

References

Jan 1, 1985·European Journal of Clinical Pharmacology·O L PedersenK Stengaard-Pedersen
Jul 3, 1999·Annals of Internal Medicine·B F CulletonD Levy
Sep 7, 2002·Hypertension·Susumu WatanabeRichard J Johnson
Sep 21, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Masafumi KuzuyaHiroshi Shimokata
Mar 12, 2004·The New England Journal of Medicine·Hyon K ChoiGary Curhan
Apr 27, 2004·Cardiovascular Drugs and Therapy·Ariel J Reyes
Oct 2, 2004·Kidney International·Stella S DaskalopoulouDimitri Mikhailidis
Nov 18, 2004·JAMA : the Journal of the American Medical Association·Richard B DevereuxBjörn Dahlöf
Aug 16, 2005·The American Journal of Cardiology·Sunao KojimaUNKNOWN Japanese Acute Coronary Syndrome Study (JACSS) Investigators
Mar 15, 2006·Circulation·Wayne C LevyMilton Packer
May 28, 2008·Archives of Internal Medicine·Eswar KrishnanUNKNOWN MRFIT Research Group
Nov 13, 2008·The Journal of Clinical Endocrinology and Metabolism·V Saroja VorugantiNedal H Arar
Jan 28, 2009·Archives of Internal Medicine·John P FormanGary C Curhan
Feb 10, 2009·International Journal of Cardiology·O James EkundayoAli Ahmed
Nov 11, 2009·Archives of Internal Medicine·Marvin Moser, Peter U Feig
Feb 12, 2010·Journal of Human Hypertension·I M PalmerH W Huisman
Oct 6, 2010·The American Journal of Cardiology·Ravi V DesaiAli Ahmed
Feb 8, 2011·BMC Medical Genomics·Bashira A CharlesCharles N Rotimi
Feb 14, 2012·The American Journal of Cardiology·Gjin NdrepepaAdnan Kastrati
Mar 1, 2012·Journal of the American College of Cardiology·Glenn A HirschRobert G Weiss
Jan 29, 2013·The American Journal of Cardiology·Shaye KivityDavid Olchovsky
Mar 2, 2013·Journal of the American College of Cardiology·Sushma RekhrajAllan D Struthers
May 16, 2013·The American Journal of Cardiology·Filippo ValbusaGiovanni Targher
Jul 19, 2013·Circulation. Heart Failure·Michael M GivertzEugene Braunwald
Apr 9, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Leonardo TamarizJoshua M Hare

❮ Previous
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Citations

Nov 8, 2015·International Journal of Cardiology·Lei ZhangZaiping Jing
Mar 1, 2018·Clinical and Experimental Pharmacology & Physiology·Ioannis AndrikouDimitrios Tousoulis
Dec 16, 2017·Expert Opinion on Drug Metabolism & Toxicology·Christos V RizosMoses S Elisaf
Jun 7, 2018·Biomarkers in Medicine·Jenna L RiisDouglas A Granger
Feb 20, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Tuomas KerolaAntti Eranti
Nov 19, 2017·Current Vascular Pharmacology·Giuseppe DattiloSerafinello P Cannavò
Apr 10, 2019·Current Pharmaceutical Design·Shuangshuang ZhangDandan Zhang
Jan 22, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Mehmet İnanir
Feb 27, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Wei-Shih HuangKuang-Hsi Chang
Jan 15, 2020·Journal of Nephrology·Barbara BoninoFrancesca Viazzi
Nov 11, 2018·Journal of Cardiovascular Translational Research·Loretta Zsuzsa KissBéla Merkely
Jan 29, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jiaqi LiUNKNOWN CIRCS investigators
Mar 19, 2019·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Alon AbrahamVera Bril
May 27, 2020·Cardiovascular Therapeutics·Flavia FranconiAnnalisa Romani
Mar 13, 2017·American Journal of Nephrology·Masanari KuwabaraRichard J Johnson
Jan 7, 2019·BMC Cardiovascular Disorders·Viera StubnovaBård Waldum-Grevbo
Jan 17, 2020·Metabolites·Camila WeschenfelderAline Marcadenti
Jun 18, 2020·World Journal of Clinical Cases·Yu-Kai LinGen-Min Lin
Mar 20, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Fatemeh Ghane Sharbaf, Farahnak Assadi
Apr 2, 2020·International Journal of Environmental Research and Public Health·Wen-Chih WuChien-An Sun
Jul 27, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Yansheng WuJiandong Gao
Nov 1, 2020·Current Hypertension Reports·Jan T KielsteinMichel Burnier
Dec 31, 2020·ESC Heart Failure·Takahide FujihashiUNKNOWN CHART-2 Investigators
Jul 28, 2020·European Journal of Internal Medicine·Marco CentolaStefano Carugo

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