Relation of Sex Hormone Levels With Prevalent and 10-Year Change in Aortic Distensibility Assessed by MRI: The Multi-Ethnic Study of Atherosclerosis

American Journal of Hypertension
Vinita SubramanyaErin D Michos

Abstract

Women experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis. We studied 1,345 postmenopausal women and 1,532 men aged 45-84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50% at baseline. Among these participants, 457 women and 548 men returned for follow-up magnetic resonance imaging 10-years later. Stratified by sex, and using mixed effects linear regression methods, we examined associations of sex hormones (as tertiles) with baseline and annual change in log-transformed AAD (mm Hg-110-3), adjusting for demographics, body size, lifestyle factors, mean arterial pressure, heart rate, hypertensive medication use (and in women, for hormone therapy use and years since menopause). The mean (SD) age was 65 (9) for women and 62 (10) years for men. AAD was lower in women than men (P < 0.001). In adjusted cross-sectional analysis, the highest tertile of free testosterone (compared to lowest) in women was significantly associated with lower AAD [-0.10 (-0.19, -0.01)] and the highest te...Continue Reading

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Citations

May 4, 2018·American Journal of Hypertension·Kaisa M Mäki-Petäjä, Ian B Wilkinson
Jul 22, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Benard O OgolaSarah H Lindsey
Aug 24, 2018·The Journal of Clinical Endocrinology and Metabolism·Wendy YingErin D Michos
Nov 5, 2020·The Journal of Obstetrics and Gynaecology Research·Derya KilicTolga Guler
Feb 24, 2021·Journal of the American Heart Association·Marie-Pierre St-OngeDhananjay Vaidya

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