Relation of symptoms to impaired stomach, small bowel, and colon motility in long-standing diabetes

Digestive Diseases and Sciences
F L IberS Reddy


Stomach, intestinal, and colonic transit were measured in males with insulin-requiring diabetes of greater than 10 years' duration to compare with symptoms and to estimate the medical significance. For all diabetics only the symptom constipation correlated with the appropriate regional delayed transit. Diabetics with delayed transit in any region, however, had more overall gastrointestinal symptoms. Diabetics with delayed transit had disease of significantly longer duration than those without delay. Delayed transit was common in the diabetics selected for study with 21 of 54 stomachs, 10 of 20 small intestines, and 14 of 20 colons showing impairment. Of 35 diabetics with impaired transit at one or more locations, only seven were judged of medical importance and five of these responded to treatment. In this study, delayed transit was frequent; in the one fifth requiring management, the symptoms related closely to the region impaired.


Feb 1, 1990·Archives of Internal Medicine·K I Ogbonnaya, R Arem
Jun 1, 1989·Digestive Diseases and Sciences·S D LadasS A Raptis
Dec 1, 1987·Journal of Clinical Gastroenterology·A Keshavarzian, F L Iber
Jan 1, 1986·Annual Review of Medicine·R E Clouse, D H Alpers
Mar 1, 1987·Archives of Internal Medicine·Y H AhnJ M Goldman
Feb 1, 1985·Annals of Internal Medicine·R N FedorakE B Chang
Mar 1, 1983·Annals of Internal Medicine·M Feldman, L R Schiller
Dec 1, 1983·The Tohoku Journal of Experimental Medicine·S KageyamaM Abe
Jul 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·R J GuyP J Watkins
Dec 30, 1982·The New England Journal of Medicine·L R SchillerJ S Fordtran


Sep 22, 2007·Current Gastroenterology Reports·Nicolas Intagliata, Kenneth L Koch
Oct 29, 2003·Diabetes Research and Clinical Practice·M OyaY Seino
Jul 16, 2003·Gastroenterology Clinics of North America·D Scott SmithChristopher D Ferris
Sep 26, 2001·Autonomic Neuroscience : Basic & Clinical·S YonedaM Takaki
Mar 14, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G Stacher
Jul 21, 2011·Diabetes Technology & Therapeutics·Satyavati RanaKartar Singh
Jun 1, 1997·Journal of Clinical Gastroenterology·H P ParkmanR S Fisher
Jul 27, 2001·Journal of Clinical Gastroenterology·L T ChouG H Chen
Sep 22, 2010·Southern Medical Journal·Nevin Akcaer OzturkUgur Yilmaz
Mar 1, 1995·British Journal of Pharmacology·M A Martinez-CuestaS Moncada
Jun 18, 1999·Annals of the New York Academy of Sciences·N VaismanP Vardi
Oct 8, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ketrija TouwB Paul Herring
Apr 24, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Naim M MaaloufKhashayar Sakhaee
Feb 6, 2014·Journal of Nephrology·Khashayar Sakhaee
Apr 25, 2006·The British Journal of Radiology·E Y HuangL M Sun
Mar 29, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·Michael HorowitzM Samsom
Aug 30, 2008·Clinical Endocrinology·Adil E BharuchaAlan R Zinsmeister
Feb 20, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A KumarS S C Rao
Sep 4, 2010·European Journal of Pain : EJP·Jens Brøndum FrøkjærAsbjørn Mohr Drewes
Jan 4, 2012·Microscopy Research and Technique·Rafael Neodini RemedioFlávio Henrique Caetano
Mar 1, 1996·Gastroenterology Clinics of North America·E M Quigley
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Reema Fayez TayyemMajed Mohammed Alnusair
Apr 30, 2002·Best Practice & Research. Clinical Gastroenterology·Jörg C Hoffmann, Martin Zeitz
Sep 2, 2011·Autonomic Neuroscience : Basic & Clinical·Joseph CelliniKathy J LePard
Jul 12, 2017·World Journal of Diabetes·Mirabella ZhaoJingbo Zhao
Nov 17, 2011·The American Journal of Gastroenterology·Rok Seon ChoungNicholas J Talley
Jun 11, 2019·Journal of Neurogastroenterology and Motility·Hyung-Min ParkMin Young Chung
Jun 8, 2004·Scandinavian Journal of Gastroenterology·M T MartínJ R Malagelada
Oct 6, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jieyun Yin, Jiande Dz Chen
Jun 26, 2001·Acta Neurologica Scandinavica·K KroghS Laurberg
Mar 18, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Pengmin ChenPing Li
Nov 1, 1998·Journal of Gastroenterology and Hepatology·Michael HorowitzRobert Fraser
May 24, 2006·World Journal of Gastroenterology : WJG·Yoshihisa UritaKazumasa Miki
May 24, 2006·World Journal of Gastroenterology : WJG·Jingbo ZhaoNiels Ejskjaer
Jun 7, 2012·Clinical Pharmacokinetics·Miroslav DostalekMartina Puzanovova

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.