PMID: 6106045Jan 1, 1980Paper

Relation of the neuroendocrine system to the development and growth of experimental mammary tumors

Journal of Neural Transmission
J Meites

Abstract

The regulation of hormonal influences on mammary tumor development and growth resides in the hypothalamus. The two major hormones essential for mammary tumor development in the rat and mouse, and also for mammary tumor growth in the rat, are prolactin and estrogen. Prolactin secretion is directly controlled by the hypothalamus, and estrogen indirectly via the pituitary gonadotropins. Treatments that increase prolactin secretion in the rat and mouse increase the incidence of spontaneous mammary tumors, whereas treatments that decrease prolactin or estrogen secretion decrease the incidence of spontaneous mammary tumors in these species. In carcinogen treated rats, either an increase or decrease in prolactin or ovarian hormones inhibits development of mammary cancers. After the appearance of mammary tumors in rats, spontaneous or carcinogen-induced, a reduction in prolactin results in reduced mammary tumor growth, and an increase in prolactin in enhanced mammary tumor growth. Either a reduction in estrogen or an excess of estrogen inhibits mammary tumor growth in rats. Large doses of estrogen inhibit mammary tumor growth by preventing prolactin from stimulating tumor growth. In mice with well established mammary tumors, prolactin ...Continue Reading

References

Jan 1, 1977·Neuroendocrinology·L GrandisonJ Meites
Jan 1, 1976·Current Topics in Molecular Endocrinology·J MeitesG D Riegle
Jan 3, 1977·European Journal of Clinical Pharmacology·H KewitzE Lindtner
Jan 1, 1977·Journal of Biological Standardization·H MirchamsyM Amin-Salehi
Jun 26, 1975·The New England Journal of Medicine·T M MackM C Pike
Sep 21, 1974·Lancet·O P HeinonenM I Turunen
Nov 1, 1974·American Journal of Surgery·J P Minton
Jul 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·P A KellyH G Friesen
Nov 9, 1974·British Medical Journal·S FranksH S Jacobs
Sep 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·G S Kledzik, J Meites
Jan 1, 1973·Journal of the National Cancer Institute·B MacMahonJ Brown
Jan 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·S K QuadriJ Meites
Mar 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·S K Quadri, J Meites
Feb 1, 1973·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A R BoynsA P Forrest
Jul 15, 1973·Harefuah·H Horn, Y Horn
Mar 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·J A ClemensJ Meites
Sep 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·J MeitesJ Clark
Jun 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·P K TALWALKERH MIZUNO

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Citations

Jan 1, 1997·Journal of Surgical Oncology·M D VolmW K Gradishar
Jan 1, 1981·Journal of Neural Transmission·V Lapin, I Ebels
Jan 1, 1984·Breast Cancer Research and Treatment·J P PeyratA Demaille
Jan 1, 1992·Breast Cancer Research and Treatment·G R Rutteman
Jun 5, 2002·Mechanisms of Ageing and Development·Srinivasan ThyagaRajan, David L Felten
Mar 7, 1998·Cancer Letters·S ThyagaRajanD L Felten
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M Ben-DavidA V Schally
Oct 1, 1992·Mayo Clinic Proceedings·A J Martinez
Sep 3, 2011·Journal of Applied Toxicology : JAT·Adam Hargreaves, Johannes Harleman
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P LissoniS Barni
Nov 1, 1982·European Journal of Cancer & Clinical Oncology·J BonneterreP Cappelaere
Nov 1, 1984·European Journal of Cancer & Clinical Oncology·J P PeyratJ Djiane
Sep 16, 2006·Critical Reviews in Toxicology·A ShippC Van Landingham
Apr 15, 2000·Frontiers in Neuroendocrinology·S Cos, E J Sánchez-Barceló
Feb 24, 2005·Molecular and Cellular Biochemistry·M C SaezE Ortega

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