Relation of ventricular size and function to heart failure status and ventricular dysrhythmia in patients with severe left ventricular dysfunction

The American Journal of Cardiology
C KoilpillaiB Shelton

Abstract

Patients with severe left ventricular (LV) dysfunction may or may not have overt heart failure and ventricular dysrhythmia. To study factors behind this variability, we examined a subset of 311 patients from the Studies of Left Ventricular Dysfunction-95 with a history of moderate heart failure (treatment trial) and 216 with no failure (prevention trial), all with ejection fractions <0.35. Echocardiographic variables were compared between trials and also correlated with dysrhythmia in 258 patients, and with neurohormones in 199 patients. Compared with prevention patients, treatment patients had larger LV end-diastolic diameter, end-systolic volume, sphericity index, and ratio of early to late diastolic filling velocity by Doppler (E/A ratio), lower LV ejection fraction and atrial contribution to ventricular filling, and similar LV mass, end-diastolic volume, and estimates of systolic wall stress. With prevention and treatment patients combined, the prevalence of abnormally elevated atrial natriuretic peptide was 92% in the highest tertile of E/A ratio compared with 55% in the lower tertiles (p=0.006). Across tertiles of LV end-diastolic volume, there was an increase in the prevalence of nonsustained ventricular tachycardia (24%...Continue Reading

References

Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Jul 1, 1986·Journal of the American College of Cardiology·R J RodehefferT Inagami
Jan 1, 1973·Circulation·P F CranefieldB F Hoffman
Mar 1, 1984·The American Journal of Cardiology·E F UretzJ V Messer

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Citations

Jan 1, 2005·Multimedia Manual of Cardiothoracic Surgery : MMCTS·Lynda Mickleborough
Jan 29, 2013·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Xin-sheng HuangQi-wen Zhou
Oct 22, 2004·Current Treatment Options in Cardiovascular Medicine·Robert M Lobel, Daniel L Lustgarten
Sep 27, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Yehoshua C LevineAlfred E Buxton
Jan 23, 2016·Journal of the American College of Cardiology·Yitschak BitonAlon Barsheshet
Jan 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Marisa Di DonatoVincent Dor
Jun 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·Lynda L MickleboroughSusan Carson
Jul 14, 1998·The American Journal of Cardiology·A Vitarelli, M Gheorghiade
Aug 5, 2000·Clinics in Geriatric Medicine·V L Sorrell, N C Nanda
May 6, 2003·The American Journal of Cardiology·Erica D Engelstein
Sep 22, 2005·Clinical and Experimental Pharmacology & Physiology·Roberto CurielMiguel Cerrolaza
Apr 24, 2012·The Journal of Thoracic and Cardiovascular Surgery·Daniel P MulloyJohn A Kern
May 9, 2006·The Journal of Thoracic and Cardiovascular Surgery·Ulrik SartipyDan Lindblom
Nov 30, 2000·Clinical Cardiology·K J HarjaiN G Pandian
Mar 25, 1998·Journal of Cardiovascular Electrophysiology·J T Vermeulen
Sep 11, 2007·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Ulrik SartipyDan Lindblom
May 1, 2008·Future Cardiology·James N Kirkpatrick, Martin G Keane
Feb 15, 2007·Journal of Palliative Medicine·Brad Stuart
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·H Schunkert
Dec 9, 2016·Journal of the American Heart Association·Derek PhanSumeet S Chugh
Sep 12, 2000·Current Cardiology Reports·P J Podrid
May 25, 2005·The American Journal of Hospice & Palliative Care·Mellar P DavisJames B Young
Dec 22, 1999·The American Journal of Physiology·R W Fasciano, L Tung
Oct 24, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Shiro NakamoriReza Nezafat

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