Abstract
We aimed to assess the association between measures of obesity and outcomes in coronary artery disease (CAD) patients. We included consecutive patients referred to cardiac rehabilitation for previous CAD events, who were classified using body mass index (BMI) groups and gender-specific tertiles of waist-to-hip ratio (WHR). Follow-up was ascertained using a population-based, record linkage system. Major cardiovascular event (MACE) was defined as the composite outcome including acute coronary syndromes, coronary revascularization, ventricular arrhythmias, stroke, or death from any cause. We used Cox proportional hazards models adjusted for potential confounders. The cohort included 1,529 patients (74% men), 63.1 ± 12.5 years (mean age ± SD), of whom 40% were obese by BMI. Eighty-eight percent of men and 57% of women were classified as having central obesity by WHR. Median follow-up was 5.7 years and 415 patients had MACE. After adjustment, a high WHR tertile was a significant predictor for MACE in women (hazard ratio [HR] 1.85, 95% confidence interval [CI] 1.16, 2.94, p = 0.01) but not in men (HR 0.92, 95% CI 0.69, 1.22, p = 0.54). This relation in women persisted after further adjustment for BMI (HR 1.75, 95% CI 1.07, 2.87, p = ...Continue Reading
References
Jan 17, 1995·Annals of the New York Academy of Sciences·Y MatsuzawaK Tokunaga
Aug 28, 2001·The American Journal of Clinical Nutrition·J C SeidellC Bouchard
Nov 14, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·E Blaak
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Nov 8, 2005·Lancet·Salim YusufUNKNOWN INTERHEART Study Investigators
Apr 12, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C LiL Janzon
Aug 22, 2006·Lancet·Abel Romero-CorralFrancisco Lopez-Jimenez
Dec 13, 2006·Archives of Internal Medicine·Jeffrey A TiceDouglas C Bauer
Apr 4, 2007·European Heart Journal·Lawrence de KoningSonia S Anand
Aug 21, 2007·Journal of the American College of Cardiology·Raphael SeeJames A de Lemos
Feb 4, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D O OkoroduduF Lopez-Jimenez
May 7, 2011·Journal of the American College of Cardiology·Thais CoutinhoFrancisco Lopez-Jimenez
Nov 20, 2012·International Journal of Epidemiology·Jennifer L St SauverWalter A Rocca
Sep 3, 2013·The American Journal of Cardiology·John A BatsisFrancisco Lopez-Jimenez
Mar 4, 2014·Mayo Clinic Proceedings·James R CerhanAmy Berrington de Gonzalez
Sep 16, 2014·The American Journal of Medicine·Alanna M ChamberlainVéronique L Roger
Oct 16, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·X SongUNKNOWN DECODE Study Group
Nov 10, 2015·Annals of Internal Medicine·Karine R SahakyanFrancisco Lopez-Jimenez
Feb 11, 2016·Mayo Clinic Proceedings·Saurabh SharmaFrancisco Lopez-Jimenez
May 5, 2016·Coronary Artery Disease·Hye Won LeeUNKNOWN Korea Working Group on Myocardial Infarction Investigators
Apr 4, 2017·Mayo Clinic Proceedings·Marta SupervíaRandal J Thomas
Citations
Sep 28, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H ReddonD Meyre
Jul 5, 2019·Cerebral Cortex·Lauren E SalminenNeda Jahanshad
Jul 10, 2020·International Heart Journal·Wen SuXue-Qiao Zhao
Aug 14, 2020·Obesity Surgery·Jaime Ruiz-TovarCarolina Llavero
Jul 3, 2019·Medicine·Ching-Feng HuangFan-Hao Chou
Aug 16, 2019·Cardiovascular Diabetology·Yaoshan DunThomas P Olson
Feb 24, 2021·The American Journal of the Medical Sciences·Yao LiHao Xue
Mar 25, 2021·Nutrición hospitalaria·Ángel Martín CastellanosFrancisco Javier Barca Durán
Aug 31, 2021·Journal of Cardiopulmonary Rehabilitation and Prevention·Philip A Ades, Patrick D Savage