Relation of white matter hyperintensities and motor deficits in chronic stroke

Restorative Neurology and Neuroscience
Jarrod HicksGitendra Uswatte

Abstract

Infarct size and location account for only a relatively small portion of post-stroke motor impairment, suggesting that other less obvious factors may be involved. Examine the relationship between white matter hyperintensity (WMH) load among other factors and upper extremity motor deficit in patients with mild to moderate chronic stroke. The magnetic resonance images of 28 patients were studied. WMH load was assessed as total WMH volume and WMH overlap with the corticospinal tract in the centrum semiovale. Hemiparetic arm function was measured using the Motor Activity Log (MAL) and Wolf Motor Function Test (WMFT). Hierarchical multiple regression models found WMH volume predicted motor deficits in both real-world arm use (MAL;ΔR2 = 0.12, F(1, 22) = 4.73, p = 0.04) and in arm motor capacity as measured by a laboratory motor function test (WMFT;ΔR2 = 0.18, F(1, 22) = 6.32, p = 0.02) over and above age and lesion characteristics. However, these models accounted for less than half of the variance in post-stroke motor deficits. The results suggest that WMH may be an important factor to consider in stroke-related upper extremity motor impairment. Nonetheless, the basis of the largest part of the post-stroke motor deficit remains unacc...Continue Reading

References

Mar 1, 1987·Stroke; a Journal of Cerebral Circulation·L D DeWittF S Buonanno
Oct 1, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J DesrosiersA Rochette
Jun 2, 2001·Archives of Physical Medicine and Rehabilitation·D M MorrisE Taub
Jul 7, 2001·Stroke; a Journal of Cerebral Circulation·S L WolfA Piacentino
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·J R MarstrandH B W Larsson
Oct 31, 2003·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Hedvig SöderlundLenore J Launer
Apr 17, 2004·Stroke; a Journal of Cerebral Circulation·J H van der LeeL M Bouter
Feb 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·P S SachdevA F Jorm
May 11, 2005·Neurorehabilitation and Neural Repair·S K SchiemanckA J H Prevo
Mar 4, 2006·Stroke; a Journal of Cerebral Circulation·Edward TaubAnjan Chatterjee
May 23, 2009·Stroke; a Journal of Cerebral Circulation·Lynne V GauthierGitendra Uswatte
Nov 6, 2009·Nature Reviews. Neuroscience·Timothy H Murphy, Dale Corbett
Apr 10, 2010·Stroke; a Journal of Cerebral Circulation·Lin L ZhuGottfried Schlaug
Aug 21, 2010·Neurobiology of Aging·Patricia LinortnerChristian Enzinger
Nov 19, 2011·Stroke; a Journal of Cerebral Circulation·Lynne V GauthierGitendra Uswatte
May 15, 2012·Archives of Physical Medicine and Rehabilitation·Timea M HodicsJohn C Pezzullo
Jul 11, 2013·Cerebrovascular Diseases·Stefan H KreiselMichael G Hennerici
Jan 9, 2014·Frontiers in Human Neuroscience·Randolph J Nudo
May 13, 2014·Neurology·Raoul P KloppenborgEsther van den Berg
Jul 16, 2014·Frontiers in Human Neuroscience·Edward TaubVictor W Mark
Sep 6, 2014·Restorative Neurology and Neuroscience·Lynne V GauthierGitendra Uswatte
May 26, 2017·Stroke; a Journal of Cerebral Circulation·Chen LinShyam Prabhakaran

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.