Relational analysis among fibrinogenic Bβ-chain gene polymorphisms and its functional expression and obesity

Obesity Research & Clinical Practice
Yuan XiaodongLi Hongfen

Abstract

Recently, there have been a few studies showing the association between obesity and fibrinogen (Fg) gene polymorphisms, but the reasons still do not clear completely. In this research, we studied the relationship among overweight, obesity and -854G/A, -455G/A, -249C/T, -148C/T, 448G/A, Bcl-1G/A gene polymorphisms of Fg β-chain and its functional expression such as plasma Fg concentration and molecule conglomerate function. 1391 subjects of retired aged employees from Kailuan Group were enrolled with medical examination and questionnaire survey, and which were divided into normal weight group (597 cases), overweight group (609 cases), obese group (185 cases) based on body mass index (BMI). Plasma Fg concentration, fibrin monomer polymerized velocity (FMPV), absorbance maximum (Amax) and FMPV/Amax were measured in all subjects. The gene polymorphisms at six sites of Fg β-chain were detected by polymerase chain reaction-restriction fragment length polymorphism. We found that only the frequencies of Bcl-1A allele and its mutated genotypes in overweight group were significantly higher than ones in normal weight group (P < 0.01). The loose linkage disequilibrium was evident between FgβBcl-1G/A and -455G/A, -148C/T polymorphisms. Fg c...Continue Reading

References

Jun 6, 2002·Biomedical and Environmental Sciences : BES·Bei-Fan Zhou, UNKNOWN Cooperative Meta-Analysis Group of the Working Group on Obesity in China
Apr 12, 2003·Obesity Research·Monica BullóJordi Salas-Salvadó

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