PMID: 8598829Feb 29, 1996Paper

Relational database model for DNA mutations and a software program for implementation of the model

Mutation Research
N F Cariello

Abstract

A relational database model for describing DNA mutations is presented. The model was developed in conjunction with the human hprt database and was successful in representing over 1800 hprt mutations. Mutants showing aberrant mRNA splicing can be adequately described using the model, as well as mutants showing more than one mutation. The basic aspects of the relational model should be applicable to mutations in a variety of genes. A data entry program developed using Microsoft Access 2.0 is also described that implements the relational model. The data entry program ensures that relational integrity is maintained between the tables and automatically generates key fields as needed. The program also has the ability to convert between the various numbering schemes that are used to describe base pair location in the hprt gene. The program and source code are placed in the public domain so that other experimenters can adapt the program for use with other genes.

References

Jan 1, 1992·Environmental and Molecular Mutagenesis·N F CarielloT R Skopek
Apr 1, 1990·Genomics·A EdwardsW Ansorge
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D J JollyT Friedmann
Apr 1, 1994·Mutation Research·N F Cariello

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Citations

Mar 12, 2013·Nucleosides, Nucleotides & Nucleic Acids·Khue Vu Nguyen, William L Nyhan
Feb 3, 1999·The American Journal of Emergency Medicine·B G Abbott, E P Monico
Jan 1, 1996·Environmental and Molecular Mutagenesis·N F Cariello, G R Douglas

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