Relations among circulating monocytes, dendritic cells, and bacterial translocation in patients with intestinal obstruction.

World Journal of Surgery
Hisanori ShiomiTohru Tani

Abstract

Little evidence is available regarding the relations among circulating monocytes, dendritic cells (DCs), and bacterial translocation (BT) in patients with intestinal obstruction. We investigated alterations in DCs in mesenteric lymph nodes (MLNs), circulating immune cells (white blood cell, lymphocyte, and monocyte counts), and BT to MLNs in 21 patients undergoing abdominal surgery because of intestinal obstruction. We also examined whether BT correlated with the development of perioperative systemic inflammatory response syndrome (SIRS) and postoperative septic complications. BT subsequent to intestinal obstruction was observed in 7 (33%) patients. Preoperative circulating immune cell counts were significantly lower in BT-positive patients than those in BT-negative patients. The presence of preoperative SIRS was also significantly related to BT-positive status. A preoperative monocyte count <290/mm(3) was the best predictive factor for BT in MLNs during intestinal obstruction: sensitivity 85.7%; specificity 92.3%; positive and negative predictive values 85.7% and 92.9%, respectively. The area under the receiver operating characteristic curve was 0.944. The expression of S-100 protein-positive DCs in MLNs significantly increase...Continue Reading

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Citations

Sep 12, 2013·Annals of Surgery·Pedro G TeixeiraDemetrios Demetriades
Jun 19, 2013·The British Journal of Nutrition·Rosana G C SantosValbert N Cardoso
Oct 25, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Marina Andrade BatistaValbert Nascimento Cardoso
Jan 23, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Pengfei WangJieshou Li
Mar 23, 2017·Langenbeck's Archives of Surgery·Shunichiro KomatsuMasato Nagino

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