Relations Among Foveal Blood Flow, Retinal-Choroidal Structure, and Visual Function in Retinitis Pigmentosa

Investigative Ophthalmology & Visual Science
Yusuke MurakamiYasuhiro Ikeda

Abstract

To investigate the relationships between foveal blood flow as measured by laser speckle flowgraphy (LSFG), the retinal-choroidal structure in enhanced depth imaging-optical coherence tomography (EDI-OCT), and central visual function in patients with retinitis pigmentosa (RP). We studied 52 consecutive typical RP patients ≤50 years old and 21 age- and sex-matched controls. The mean blur rate (MBR), which represents the blood flow volume, was calculated in a 2.4-mm2 area centered on the fovea by LSFG. Subfoveal horizontal EDI-OCT images were recorded, and the choroidal area, choroidal hyporeflective area, and choroidal hyperreflective area were analyzed in the central 2.4-mm-wide region. The central foveal thickness (CFT), subfoveal choroidal thickness (SCT), and ellipsoid zone (EZ) width were also measured. Visual acuity (VA) and retinal sensitivity (Humphrey 10-2 program) were measured in the RP patients. The MBR, choroidal area, hyporeflective area, hyperreflective area, and SCT were significantly decreased in the RP patients (all P < 0.001, versus controls). Spearman's rank testing demonstrated no significant correlation between the MBR and the choroidal structural parameters in the RP patients. Decreased MBR was significantl...Continue Reading

Citations

Nov 30, 2019·BioMed Research International·Mitsuru NakazawaSei-Ichi Ishiguro
Nov 13, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ebru N CetinGökhan Pekel
Oct 29, 2019·Investigative Ophthalmology & Visual Science·Masataka IshizuYasuhiro Ikeda
Aug 22, 2020·Translational Vision Science & Technology·Giacomo CalzettiLeopold Schmetterer
May 14, 2021·The British Journal of Ophthalmology·Malena Daich VarelaMichel Michaelides
Jun 18, 2021·American Journal of Ophthalmology Case Reports·Nana TakahashiToru Nakazawa
Apr 20, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Paolo CorazzaMassimo Nicolò

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