Relations among maternal withdrawal in infancy, borderline features, suicidality/self-injury, and adult hippocampal volume: A 30-year longitudinal study

Behavioural Brain Research
J E KhouryKarlen Lyons-Ruth

Abstract

The hippocampus plays an important role in stress regulation and has been the focus of research regarding the effects of early life stress on brain development. Much of this research has focused on severe forms of early adversity, particularly maltreatment. However, a handful of studies are now examining the effects of more subtle variations in quality of early caregiving on hippocampal development. In addition, both early caregiving and hippocampal volumes have been linked to psychopathology, particularly borderline personality disorder (BPD) and its associated features, such as suicidality. In the context of a 30-year longitudinal study, we assessed associations between maternal withdrawal in infancy, hippocampal volume, and BPD features in adulthood. Hippocampal volume was assessed among 18 adults (29.33 ± 0.49 years) assessed for caregiving quality at 18 months (M =18.55 months, SD = 1.21 months) and followed longitudinally to age 29. Left hippocampal volume in adulthood was associated with maternal withdrawal in infancy, but not by other components of disrupted parenting. Other risk factors, including maternal psychosocial risk and severity of maltreatment in childhood, were not significantly related to left hippocampal vo...Continue Reading

Citations

Aug 14, 2020·Issues in Mental Health Nursing·Tamara Pike Keefner, Thomas Stenvig
Aug 21, 2020·Current Opinion in Psychology·Karlen Lyons-Ruth, Laura E Brumariu
Dec 18, 2020·Molecular and Cellular Endocrinology·Lucy BabicolaMatteo Di Segni
Nov 28, 2020·European Journal of Psychotraumatology·Camille Guérin-MarionJean-François Bureau
Apr 24, 2021·Attachment & Human Development·John D HaltiganSoha Khorsand

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