Relations between aortic stiffness and left ventricular structure and function in older participants in the Age, Gene/Environment Susceptibility--Reykjavik Study

Circulation. Cardiovascular Imaging
Vanessa BellGary F Mitchell

Abstract

Left ventricular (LV) contraction displaces the aortic annulus and produces a force that stretches the ascending aorta. We hypothesized that aortic stiffening increases this previously ignored component of LV load and may contribute to hypertrophy. Conversely, aortic stretch-related work represents stored energy that may facilitate early diastolic filling. We performed MRI of the aorta and LV in 347 participants (72-91 years old, 189 women) in the Age, Gene/Environment Susceptibility-Reykjavik Study to examine relations of aortic stretch with LV structure and function. Aortic stiffness was evaluated as the product of Young's modulus and aortic wall thickness. Force was computed from Young's modulus and longitudinal aortic strain; work was the integrated product of force and annulus displacement during systole. LV mass and dynamic volume were measured using the area-length method. Filling was assessed from time-resolved LV volume curves. In multivariable models that adjusted for age, sex, height, weight, end-diastolic LV volume, augmentation index, end-systolic pressure, and cardiovascular disease risk factors, higher aortic stiffness was associated with increased LV mass (β=3.0±0.8% per SD, P<0.001; sex interaction, P=0.8). Gre...Continue Reading

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Citations

Apr 4, 2017·Journal of the American Society of Hypertension : JASH·Hamza BelloAngela J Woodiwiss
Apr 27, 2018·Journal of Hypertension·Marijana TadicGuido Grassi
Jan 11, 2017·Journal of the American Heart Association·Vanessa BellSusan Cheng
Mar 27, 2016·Journal of the American Heart Association·Bernhard M KaessGary F Mitchell
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Oct 26, 2018·Journal of Applied Physiology·Gary F Mitchell
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Jun 12, 2017·The Kaohsiung Journal of Medical Sciences·Narin Nasıroglu ImgaSerdar Guler
Feb 26, 2021·Scientific Reports·Piotr KarwatJerzy Litniewski
Apr 2, 2021·Circulation Research·Pierre BoutouyrieGary F Mitchell

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