Relations between endogenous androgens and estrogens in postmenopausal women with suspected ischemic heart disease.

The Journal of Clinical Endocrinology and Metabolism
Glenn D BraunsteinC Noel Bairey Merz

Abstract

Because androgens are obligatory precursors of estrogens, it is reasonable to assume that their serum concentrations would exhibit positive correlations. If so, then epidemiologic studies that examine the association between androgens and pathological processes should adjust the results for the independent effect of estrogens. The objective of the study was to examine the interrelationships among testosterone (T), androstenedione, estradiol (E2), estrone, and SHBG in postmenopausal women. This was a cross-sectional study of women participating in the National Heart, Blood, and Lung Institute-sponsored Women's Ischemia Syndrome Evaluation study. The study was conducted at four academic medical centers. A total of 284 postmenopausal women with chest pain symptoms or suspected myocardial ischemia. Post hoc analysis of the relationships among sex steroid hormones with insulin resistance, body mass index (BMI), and presence or absence of coronary artery disease as determined by coronary angiography. BMI was significantly associated with insulin resistance, total E2, free E2, bioavailable E2, and free T. Highly significant correlations were found for total T, free T, and androstenedione with total E2, free E2, bioavailable E2, and es...Continue Reading

References

Jun 1, 1992·American Journal of Epidemiology·C F GarlandK T Khaw
May 1, 1987·American Journal of Epidemiology·D K WysowskiH L Lau
May 1, 1973·The Journal of Clinical Endocrinology and Metabolism·U GoebelsmannD R Mishell
Jun 15, 1974·American Journal of Obstetrics and Gynecology·U GoebelsmannD R Mishell
Nov 4, 1995·BMJ : British Medical Journal·E Barrett-Connor, D Goodman-Gruen
Dec 1, 1995·The Journal of Clinical Endocrinology and Metabolism·H G BurgerC Morse
Jan 1, 1996·The Journal of Clinical Investigation·C SlemendaC C Johnston
Mar 6, 1996·Journal of the National Cancer Institute·F BerrinoG Secreto
Nov 1, 1996·Clinical Endocrinology·J Bancroft, E H Cawood
Apr 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·G B PhillipsT Y Jing
Sep 10, 1998·Journal of the National Cancer Institute·S E HankinsonF E Speizer
Jun 18, 1999·The Journal of Clinical Endocrinology and Metabolism·G P BerniniA Salvetti
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Apr 18, 2002·Journal of the National Cancer Institute·T KeyUNKNOWN Endogenous Hormones and Breast Cancer Collaborative Group
Dec 7, 2002·International Journal of Cardiology·Agnieszka KaczmarekPiotr Ponikowski
Apr 3, 2003·International Journal of Cancer. Journal International Du Cancer·Herbert YuWei Zheng
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Grace Mariko KalishUNKNOWN Postmenopausal Estrogen/Progestin Intervention Trial
Sep 17, 2003·Circulation·Kathryn M RexrodeJulie E Buring
Oct 25, 2003·Cancer Causes & Control : CCC·Jonas ManjerPer Lenner
Dec 4, 2003·International Journal of Cancer. Journal International Du Cancer·Annekatrin LukanovaAnne Zeleniuch-Jacquotte
Feb 19, 2004·Cancer Causes & Control : CCC·Susan R SturgeonLouise A Brinton
Sep 8, 2004·International Journal of Cancer. Journal International Du Cancer·Andrea MicheliFranco Berrino
Nov 13, 2004·International Journal of Cancer. Journal International Du Cancer·Anne Zeleniuch-JacquottePaolo Toniolo
Dec 17, 2004·Journal of the National Cancer Institute·Stacey A MissmerSusan E Hankinson
Apr 21, 2005·The Journal of Clinical Endocrinology and Metabolism·Nanette SantoroGerson Weiss
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Catherine SchairerMark E Sherman
May 17, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stacey A MissmerSusan E Hankinson
May 27, 2006·European Journal of Endocrinology·Irene LambrinoudakiDimitrios Botsis
Aug 9, 2006·International Journal of Cancer. Journal International Du Cancer·Laila AdlyCatherine Schairer
Oct 5, 2006·Journal of the National Cancer Institute·A Heather EliassenSusan E Hankinson
Oct 13, 2006·Obesity·Anne McTiernanUNKNOWN Women's Health Initiative Investigators
Nov 9, 2006·The Journal of Clinical Endocrinology and Metabolism·William RosnerHershel Raff

❮ Previous
Next ❯

Citations

Jan 22, 2010·International Journal of Impotence Research·J S Brand, Y T van der Schouw
Jan 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Marcello MaggioLuigi Ferrucci
Jul 28, 2013·Clinical and Experimental Nephrology·Nobuaki ShirakiTakao Masaki
Dec 14, 2011·Journal of Women's Health·Chrisandra ShufeltGlenn D Braunstein
Jan 20, 2016·Resuscitation·Charles D Deakin
May 25, 2013·Endocrinology and Metabolism Clinics of North America·Carolyn J Crandall, Elizabeth Barrett-Connor
Jan 14, 2012·Obesity·Stefanie LiedtkeKaren Steindorf
May 23, 2018·Menopause : the Journal of the North American Menopause Society·Jae Hee KangLouis R Pasquale
Feb 27, 2014·Menopause : the Journal of the North American Menopause Society·Risa MaruokaMasahide Ohmichi
Jul 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Susan R DavisUNKNOWN ASPREE Investigator Group
Apr 27, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.