DOI: 2002.00094Feb 12, 2020Paper

Relations between large scale brain connectivity and effects of regional stimulation depend on collective dynamical state

ArXiv
Lia PapadopoulosDanielle S. Bassett

Abstract

At the macroscale, the brain operates as a network of interconnected neuronal populations, which display rhythmic dynamics that support interareal communication. Understanding how stimulation of a particular brain area impacts such concerted activity is important for gaining basic insights into brain function and for developing neuromodulation as a therapeutic tool. However, it remains difficult to predict the downstream effects of focal stimulation. Specifically, little is known about how the collective oscillatory regime of network activity may affect the outcomes of regional perturbations on cooperative dynamics. Here, we combine connectome data and biophysical modeling to begin filling these gaps. By tuning parameters that control the collective dynamics of the network, we identify distinct states of simulated brain activity, and investigate how the distributed effects of stimulation manifest in different states. When baseline oscillations are weak, the stimulated area exhibits enhanced power and frequency, and due to network interactions, nearby regions develop phase locked activity in the excited frequency band. Importantly, we find that focal stimulation also causes more distributed modifications to network coherence a...Continue Reading

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