Relations between neuropeptides and gut hormones

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
G J Dockray, R A Gregory

Abstract

Certain peptides have a dual distribution in brain and in neurons or endocrine cells, or both, in the gut. Substance P, neurotensin and somatostatin have been isolated from brain and gut (or pancreas); cholecystokinin has been isolated from intestine as peptides of 33 and 39 residues and their active C-terminal octapeptide has been isolated from brain, which suggests differences between biosynthetic processing pathways for cholecystokinin in neurons and those in endocrine cells. Identification of other peptides (vasoactive intestinal peptide, bombesin, enkephalin etc.) rests in part on immunochemical evidence and needs to be confirmed by isolation. The combined evidence of immunochemical and physiological studies suggests that gut target cells can receive peptides in at last four ways: (1) as hormones in the blood; (2) from intrinsic neurons in the enteric plexuses; (3) from extrinsic nerves like the vagus; (4) by local (paracrine) release from mucosal endocrine-like cells, possibly by basal axon-like processes.

Citations

Jan 1, 1985·Psychoneuroendocrinology·W A Banks, A J Kastin
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P J RzasaE K Prokop
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K V Kaloustian, J A Edmands
Oct 12, 2001·Brain Research Bulletin·S Holmgren, J Jensen
Mar 1, 1986·General and Comparative Endocrinology·R Acher
Dec 15, 1982·Biochemical and Biophysical Research Communications·M MoriJ F Wilber
May 1, 1983·British Journal of Pharmacology·S R BloomR J Unwin
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·M Ebadi, Y Hama
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·N Geary
Apr 1, 1989·Journal of Neuroendocrinology·E Bobbioni-Harsch, B Jeanrenaud
Jan 1, 1985·Annals of the New York Academy of Sciences·P J Kulkosky
Jan 1, 1986·Journal of Neuroscience Research·X G ZhuJ C Thompson
Mar 1, 1982·Klinische Wochenschrift·D Grube

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