Relations between plasma von Willebrand factor or endothelin-1 and restenosis following carotid artery stenting

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
Hua YangLe-Xin Wang

Abstract

This study was designed to investigate the relation between plasma von Willebrand factor (VWF) or endothelin-1 (ET-1) and post-carotid artery stenting (CAS) restenosis. Plasma levels of VWF and ET-1 were measured in 61 patients (36 males, mean age 64.4 ± 6.8 years) before and after CAS. The mean follow-up time was 13.8 ± 1.7 months (range, 6-63). In-stent restenosis was defined as a >10% narrowing of the vascular lumen with or without ischemic symptoms following CAS. In-stent restenosis was identified in 14 (23%) patients, including 3 with >50% restenosis. In the restenosis group, mean VWF and ET-1 levels at 2 weeks, 1 and 6 months after CAS were higher than the baseline levels (p < 0.05 or p < 0.01). Mean levels of VWF and ET-1 in the restenosis group were higher than in the non-restenosis group within 6 months after CAS (p < 0.05 or p < 0.01). Persistent elevation in plasma VWF and ET-1 within the first 6 months of CAS was found in patients with in-stent restenosis.

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Citations

Jul 22, 2014·Clinical and Translational Science·Kai Yin, Devendra K Agrawal
Aug 31, 2017·Bulletin of Experimental Biology and Medicine·K L KozlovA O Drobintseva
Apr 25, 2017·Vascular·Zhengze Dai, Gelin Xu

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