PMID: 6162877Oct 1, 1980Paper

Relations between serum levels of TSH, TBG, T4, T3, rT3 and various histologically classified chronic liver diseases

Journal of Endocrinological Investigation
M L'ageH Schleusener

Abstract

Serum levels of TSH, thyroxine-binding globulin (TBG), T4, T3 and reverse T3 (rT3) were measured in 36 patients with fatty liver disease, 11 patients wih chronic persistent hepatitis, 17 patients with chronic active hepatitis, and 29 patients with liver cirrhosis. TBG was significantly above normal levels in both groups of chronic hepatitis, the slight concomitant T4 and T3 increase was significant only for T4 in chronic persistent hepatitis. A significant decrease in T4 and T3 concentration was found in fatty liver disease and in hepatic cirrhosis. A shift in T4 conversion to rT3 could exclusively be demonstrated for the group of hepatic cirrhosis, reflected by a significant increase in rT3. As our findings indicate normal TSH levels and a lack of clinical signs of hypothyroidism in chronic liver disease, the possibility of diverse regulating changes must be considered.

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Citations

Apr 1, 1984·Journal of Endocrinological Investigation·J Ordóñez-LlanosJ A Gómez-Gerique
Oct 5, 2013·Best Practice & Research. Clinical Gastroenterology·Patrizia Burra
May 11, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Karim GarianiLorenzo A Orci
May 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Till IttermannHenry Völzke
Oct 1, 2013·Thyroid : Official Journal of the American Thyroid Association·Joshua M EstradaOffie P Soldin
Sep 1, 1993·Journal of Gastroenterology and Hepatology·Y IlanR Tur-Kaspa
May 1, 1995·Journal of Gastroenterology and Hepatology·M J Huang, Y F Liaw
Jan 8, 2013·Endocrine Journal·Debora Lucia Seguro DanilovicSuemi Marui
Jun 19, 2002·Arquivos De Gastroenterologia·M NovisH S Coelho
Jan 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W J KalkJ Levin
Oct 1, 1994·The Journal of Pediatric Endocrinology·T PasqualiniD D'Agostino

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