PMID: 6113176May 1, 1981Paper

Relations between steroid-cell contact, steroid-binding and induction of tyrosine aminotransferase

Molecular and Cellular Endocrinology
E M GiesenG Beck

Abstract

The induction of tyrosine aminotransferase by a variety of steroids was studied in cells from a hepatoma tissue culture (HTC). We have defined a class of steroids that induce TAT synthesis to a higher level than optimal inducers described earlier; these are called supra-inducers. When TAT induction is compared with the binding of the steroids to the cytoplasmic receptor or to their binding in the whole cell, a good correlation between binding in vivo of the hormone and its induction capacity can be established, whereas such a correlation was not systematically observed in vitro. A very short exposure of HTC cells to either dexamethasone or corticosterone is sufficient to induce TAT. When the inducer is removed from the culture medium a few minutes after its administration, the intracellular hormone concentration decreases very rapidly but TAT will be synthesized at its maximal rate. Thus the hormones behave as a starting signal for the optimal synthesis of the enzyme, and their presence in the culture medium is not necessary throughout the entire induction period.

References

Sep 1, 1979·Molecular and Cellular Endocrinology·E B ThompsonG L Hager
Sep 1, 1975·Journal of Steroid Biochemistry·P de MoorG Verhoeven
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R A SteinbergG M Tomkins
Sep 25, 1973·Journal of Molecular Biology·G G RousseauG M Tomkins
Jan 1, 1966·Cold Spring Harbor Symposia on Quantitative Biology·G M TomkinsB Peterkofsky
Jan 14, 1972·Science·B B LevinsonG M Tomkins
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S J HigginsG M Tomkins
Jul 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·E B ThompsonJ F Curran
Apr 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D W Martin, G M Tomkins
Aug 28, 1970·Journal of Molecular Biology·H H Samuels, G M Tomkins
May 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J D Baxter, G M Tomkins
Jun 14, 1972·Journal of Molecular Biology·G G RousseauG M Tomkins
Jul 1, 1969·The Journal of Clinical Endocrinology and Metabolism·S G KorenmanT P McCallum

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Citations

Nov 1, 1982·Journal of Steroid Biochemistry·O Bakke, K B Eik-Nes
Jan 1, 1984·Journal of Steroid Biochemistry·S Golaz, G Beck
Nov 1, 1986·Journal of Steroid Biochemistry·J P Raynaud, T Ojasoo
Oct 1, 1988·Journal of Steroid Biochemistry·G TeutschJ P Raynaud

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