Relations between subclinical disease markers and type 2 diabetes, metabolic syndrome, and incident cardiovascular disease: the Jackson Heart Study.

Diabetes Care
Vanessa XanthakisErvin R Fox

Abstract

The presence of subclinical disease measures has been directly associated with the development of cardiovascular disease (CVD) in whites. African Americans (AAs) in the U.S. are at higher risk of CVD compared with non-Hispanic whites; however, data on the prevalence of subclinical disease measures in AAs and their association to CVD remain unclear and may explain the higher CVD risk in this group. We evaluated 4,416 participants attending the first examination of the Jackson Heart Study (mean age 54 years; 64% women) with available subclinical disease measures. There were 1,155 participants (26%) with subclinical disease, defined as the presence of one or more of the following: peripheral arterial disease, left ventricular hypertrophy, microalbuminuria, high coronary artery calcium (CAC) score, and low left ventricular ejection fraction. In cross-sectional analyses using multivariable-adjusted logistic regression, participants with metabolic syndrome (MetS) or diabetes (DM) had higher odds of subclinical disease compared with those without MetS and DM (odds ratios 1.55 [95% CI 1.30-1.85] and 2.86 [95% CI 2.32-3.53], respectively). Furthermore, the presence of a high CAC score and left ventricular hypertrophy were directly assoc...Continue Reading

References

Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Oct 26, 2005·Atherosclerosis·Matthew J BudoffRoger S Blumenthal
Aug 1, 2006·International Journal of Cardiology·Ambarish GopalMatthew J Budoff
Oct 31, 2006·American Heart Journal·Sarwar H OrakzaiRoger S Blumenthal
Sep 4, 2007·Journal of the American College of Cardiology·Khurram NasirMatthew J Budoff
Dec 7, 2010·Annals of Epidemiology·Lynne E WagenknechtBarry I Freedman
Nov 1, 2012·The International Journal of Cardiovascular Imaging·Bobby W TullosHerman A Taylor
Dec 20, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee

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Citations

Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 18, 2015·Circulation·UNKNOWN Writing Group MembersUNKNOWN Stroke Statistics Subcommittee
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jul 3, 2019·Biology of Sex Differences·Jessica L Faulkner, Eric J Belin de Chantemèle
Jul 2, 2020·Metabolic Syndrome and Related Disorders·Yaira Barranco-RuizRobinson Ramírez-Vélez
Nov 17, 2020·Experimental Gerontology·Stephen D AntonMarco Pahor
May 19, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kristen M GeorgeRachel A Whitmer
Aug 14, 2021·Journal of the American Heart Association·Feven AtaklteVanessa Xanthakis
Aug 14, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kristen M GeorgeRachel A Whitmer

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