PMID: 6414193Aug 1, 1983Paper

Relations between ventricle function, myocardial oxygen consumption and coronary circulation following sublingual administration of nitroglycerin

Zeitschrift für Kardiologie
N HahnP Spiller

Abstract

The relationships between ventricular function, coronary blood flow, and myocardial oxygen consumption after sublingual administration of 1.6 mg nitroglycerin (TNG) were investigated in 12 patients. Left ventricular volumes, determined from cineventriculograms (enddiastolic volume index and endsystolic volume index), decreased (p less than 0.005) after TNG, as did left ventricular peak pressure (p less than 0.01), left ventricular enddiastolic pressure (p less than 0.005), mean aortic pressure (p less than 0.005), and mean pulmonary artery pressure (p less than 0.001). Due to the decrease in enddiastolic volume and the insignificant change in stroke volume, ejection fraction increased (p less than 0.05). Heart rate did not change significantly. In spite of an increase in the vessel diameter (13%, p less than 0.005), systolic and diastolic coronary blood flow, measured by means of a photodensitometric technique, decreased insignificantly by an average of approx. 15%. Similarly the change in myocardial oxygen consumption, calculated according to Bretschneider, decreased insignificantly by an average of approx. 10%. The correlation of changes in coronary blood flow and myocardial oxygen consumption was evaluated statistically by t...Continue Reading

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.