Relations of APOE promoter polymorphisms to LDL cholesterol and markers of subclinical atherosclerosis in young adults.

Journal of Lipid Research
Leena E ViiriTerho Lehtimäki

Abstract

The common apolipoprotein E (apoE) gene (APOE) epsilon2/epsilon3/epsilon4 polymorphism explains part of serum lipid variation, and polymorphisms in the APOE promoter region have been proposed to participate in the regulation of serum lipid levels within the most common APOE epsilon3/epsilon3 genotype group. We determined APOE -219G/T and +113G/C promoter genotypes and estimated APOE haplotypes in 525 participants of the Cardiovascular Risk in Young Finns Study. We studied the associations of the APOE promoter polymorphisms and their haplotypes with cross-sectional and longitudinal serum lipid and apolipoprotein concentrations as well as with flow-mediated dilatation (FMD), carotid artery compliance (CAC), and intima-media thickness (IMT) within the APOE epsilon3/epsilon3 carriers. We found no significant association between the APOE promoter genotypes and serum lipids [low density lipoprotein-cholesterol (LDL-C), HDL-C, and triglycerides], apolipoproteins (apoA-I and apoB), or brachial artery FMD, CAC, or carotid IMT in either men or women. In longitudinal analyses in males, the carriers of heterozygous genotypes (-219G/T or +113G/C) and, furthermore, carriers of the -219T/+113C/epsilon3 haplotype had significantly higher LDL-C...Continue Reading

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Citations

Feb 28, 2008·European Journal of Human Genetics : EJHG·Shérine AbboudReijo Laaksonen
Oct 25, 2007·Nature Clinical Practice. Cardiovascular Medicine·Rebecca L Pollex, Robert A Hegele
Dec 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Paula GrönroosTerho Lehtimäki
Oct 11, 2007·Pharmacogenomics·George V Z Dedoussis
Aug 21, 2010·Metabolism: Clinical and Experimental·Evrim Komurcu-BayrakNihan Erginel-Unaltuna
May 22, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Hideo FukunagaToshiaki Shimizu
Dec 25, 2009·Circulation. Cardiovascular Genetics·Leena E ViiriPekka J Karhunen
Jan 27, 2019·Scientific Reports·Juho-Pekka KarjalainenTerho Lehtimäki

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