Relationship among acid secretion, antral distension, and liquid gastric emptying in active and healed duodenal ulcer

Digestive Diseases and Sciences
G MaconiG Bianchi Porro

Abstract

The aim of this study was to assess the relationship between fasting antral distension and basal and maximal acid output and to examine the link between the gastric emptying rate of liquids and the amount of acid secretion. Twenty consecutive male patients with H. pylori-positive noncomplicated duodenal ulcer disease received a measurement of basal and maximal gastric acid secretion and underwent ultrasonographic (US) evaluation of fasting antral distension and gastric emptying of liquids on two separate days. Ten of these patients were studied again three months after ulcer healing. The width of the fasting antral area was not correlated with basal acid output, but a significant relationship was found between maximal acid output and fasting antral distension (r = 0.55; P = 0.012). No significant correlations were found between gastric emptying and gastric acid output. The gastric emptying rate, expressed as half-time gastric emptying and remaining liquid component at 60 min, was not influenced by basal or maximal acid output. After ulcer healing, no correlations were found between acid secretion, fasting antral distension, and gastric emptying rate. Our results suggest that in duodenal ulcer patients, fasting antral distension...Continue Reading

Citations

Dec 4, 2004·Nuclear Medicine Communications·Olivier CouturierYves Bizais
Jun 28, 2017·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Masayuki UchidaKimiko Shimizu
Jul 1, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-C SuC-M Jan

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