Relationship among prevalence of patients with Itai-itai disease, prevalence of abnormal urinary findings, and cadmium concentrations in rice of individual hamlets in the Jinzu River basin, Toyama prefecture of Japan

International Journal of Environmental Health Research
Takeshi OgawaKoji Nogawa

Abstract

This study investigated the associations among prevalence of patients with Itai-itai disease, and prevalence of abnormal urinary findings and cadmium (Cd) concentrations in rice in individual hamlets of the Jinzu River basin. From the 13,183 participants of the 1967 and 1968 health examinations, we selected 3,094 subjects as the target population who had resided in the current hamlet for a total of 30 years or longer and aged >/=50 years, and in the hamlet both the Cd concentration in rice and prevalence of patients with Itai-itai disease were known. When the inhabitants were divided into four groups according to the Cd concentration in rice or prevalence of abnormal urinary findings, significant relationships among three factors (Cd concentration in rice, prevalence of abnormal urinary findings and prevalence of patients with Itai-itai disease) were demonstrated clearly using the Cochran-Armitage test. Correlation coefficients among the three factors in 55 hamlets showed that the prevalence of the patients with Itai-itai disease increased according to increases in the mean Cd concentration in rice and increasing prevalence of urinary findings. This study demonstrated that Itai-itai disease is induced by exposure to environment...Continue Reading

References

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Citations

Mar 24, 2006·Archives of Toxicology·Hyogo HoriguchiFujio Kayama
Dec 19, 2008·Biological Trace Element Research·Etsuko KobayashiHideaki Nakagawa
Jul 21, 2006·International Journal of Environmental Health Research·Mirei UetaniKoji Nogawa
May 5, 2007·International Journal of Environmental Health Research·Mirei UetaniKoji Nogawa
Jul 12, 2013·TheScientificWorldJournal·Robin A Bernhoft
Oct 16, 2012·Bulletin of Environmental Contamination and Toxicology·Yingyot KaewnateSurapon Tangvarasittichai
Feb 20, 2007·Toxicology Letters·Wimonrat TeeyakasemWerawan Ruangyuttikarn
Jul 12, 2005·Toxicology Letters·Takeya InabaKoji Nogawa
Sep 26, 2006·Environmental Research·Marie VahterMarika Berglund
Dec 7, 2007·Environmental Research·Charles J Everett, Ivar L Frithsen
Mar 11, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jean-Claude AmiardWen-Xiong Wang
Nov 9, 2010·Ecotoxicology and Environmental Safety·Ping LiPeng Liang
Feb 25, 2017·Food & Function·Yingying HuangZhongyi Yang
May 18, 2019·Epidemiology and Health·Yongho Jee, Sung-Il Cho
May 7, 2020·Advanced Pharmaceutical Bulletin·Velid UnsalEngin Kölükçü
Jul 19, 2017·BioFactors·Mohammad MohajeriAmirhossein Sahebkar
Dec 29, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Jae Hyeon ParkHyung Sik Kim
Dec 11, 2020·The Science of the Total Environment·Marta Wacewicz-MuczyńskaMaria H Borawska
Nov 8, 2020·Seminars in Cell & Developmental Biology·Daren L Knoell, Todd A Wyatt

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