Relationship among pulmonary function, bronchial hyperresponsiveness, and atopy in children with clinically stable asthma.

Lung
Eugene YangK W Kim

Abstract

Pulmonary function testing plays a key role in the diagnosis and management of asthma in children. However, the literature does not clearly show whether children with clinically stable asthma have significantly reduced lung function when compared with normal children. We compared the lung function of 242 clinically stable asthmatic children who were initially diagnosed with mild intermittent or mild persistent asthma with the lung function of 100 nonasthmatic controls. The lung function was assessed using FEV1, FEV1/FVC, FEF25-75 and PEF. In addition, we measured bronchial hyperresponsiveness (BHR) using the provocation concentration of methacholine needed to produce a 20% fall in FEV1. All measures of pulmonary function were significantly decreased in the children with asthma. Pulmonary function was not influenced by atopy, serum IgE, or total eosinophil count (TEC). However, the likelihood ratio for trends revealed a significant association between our pulmonary parameters and the degree of BHR. Children with mild-to-severe BHR had greatly decreased lung function compared with those with normal BHR, the control group. In addition, a direct correlation was found between PC20 and our pulmonary parameters in asthmatic children. ...Continue Reading

References

Aug 1, 1992·Journal of Epidemiology and Community Health·T Nakadate, J Kagawa
Jan 1, 1991·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·A L Foo, P D Sly
Oct 1, 1990·The Journal of Allergy and Clinical Immunology·P VerdianiA Baronti
Dec 1, 1989·The American Review of Respiratory Disease·P K JefferyA B Kay
Jul 1, 1988·The American Review of Respiratory Disease·W J KellyA Olinsky
Jun 1, 1972·The American Journal of Medicine·E R McFadden, D A Linden
Jun 14, 1980·British Medical Journal·A J MartinP D Phelan
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·J B Clough, S T Holgate
May 1, 1993·Allergy·E Mosfeldt LaursenC Koch
Jul 1, 1993·Pediatric Pulmonology·P LebecqueA L Coates
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·J Schwartz, S T Weiss
Dec 1, 1995·Pediatric Pulmonology·R B KleinA Mansell
Dec 1, 1996·Allergy·M H GrolD S Postma
Jan 20, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M SilvestriG A Rossi
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·E CrimiV Brusasco
May 1, 1998·The Journal of Allergy and Clinical Immunology·P J Barnes
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·P G GibsonR L Clancy
Sep 14, 1999·The Journal of Allergy and Clinical Immunology·J E Fish, S P Peters
Sep 29, 1999·Statistical Methods in Medical Research·D E Shapiro
Sep 22, 2000·Archives of Disease in Childhood·I MaleP Seddon
Oct 12, 2000·The New England Journal of Medicine·UNKNOWN Childhood Asthma Management Program Research GroupRobert Zeiger
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·A L FuhlbriggeS T Weiss
Mar 14, 2001·Journal of Tropical Pediatrics·V H RatageriV Seth
Apr 18, 2002·Allergologia et immunopathologia·F GürkanK Haspolat

❮ Previous
Next ❯

Citations

Oct 25, 2006·Annual Review of Medicine·Pedro C Avila
May 7, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Tmirah HaselkornUNKNOWN TENOR Study Group
Sep 13, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Lisa J MeltzerStanley J Szefler
Nov 15, 2008·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Moema Nudilemon ChatkinEdgar Fiss

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.