Relationship among symptom clusters, quality of life, and treatment-specific optimism in patients with cancer

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Martin MatzkaHanna Mayer

Abstract

There is increasing evidence that disease and therapy-related symptoms frequently co-occur in so-called symptom clusters (SCs), which may significantly impair quality of life in patients with cancer. Although psychosocial resources may play pivotal roles in maintaining or improving quality of life, they have been neglected in SC research. Therefore, we aim to identify SCs and their relative impact on quality of life when psychosocial resources are accounted for. Patients with cancer (n = 304) undergoing chemotherapy or chemo-radiation therapy participated in a cross-sectional survey consisting of measures assessing symptoms, quality of life, resilience, treatment-specific optimism (TSO), and social support. Exploratory factor analyses and multiple regression analyses were used to identify SCs and significant explanatory variables of overall quality of life. Fatigue-pain, anxiety-depression, cancer therapy-related toxicity, and nausea-vomiting clusters were identified. In our final model, the fatigue-pain cluster (β = - 0.41, p < 0.001), nausea-vomiting cluster (β = - 0.28, p < 0.001), TSO (β = 0.21, p < 0.001), and receiving chemo-radiation treatment (β = - 0.11, p = 0.03) accounted for 44% of variance in overall quality of lif...Continue Reading

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Citations

Jun 5, 2019·Journal of Clinical Nursing·Min GuoGongchao Wang
Aug 3, 2020·Current Opinion in Supportive and Palliative Care·Antoine DesiletsDenis Soulières
Jun 23, 2018·Frontiers in Immunology·Jessica C Santos, Leah M Pyter
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Jan 4, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Han WangJie Zhao
Nov 6, 2020·Journal of Pain and Symptom Management·John F MondanaroJoanne V Loewy
Dec 19, 2021·BMJ Supportive & Palliative Care·Carolyn S HarrisChristine A Miaskowski

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