Abstract
Acetaldehyde is the first metabolite of ethanol and is produced in the epithelium by mucosal ALDH, while higher levels are derived from microbial oxidation of ethanol by oral microflora such as Candida species. However, it is uncertain whether acetaldehyde concentration in human breath is related to oral condition or local production of acetaldehyde by oral microflora. The aim of this pilot study was to investigate the relationship between physiological acetaldehyde concentration and oral condition in healthy volunteers. Sixty-five volunteers (51 males and 14 females, aged from 20 to 87 years old) participated in the present study. Acetaldehyde concentration in mouth air was measured using a portable monitor. Oral examination, detection of oral Candida species and assessment of alcohol sensitivity were performed. Acetaldehyde concentration [median (25%, 75%)] in mouth air was 170.7 (73.5, 306.3) ppb. Acetaldehyde concentration in participants with a tongue coating status score of 3 was significantly higher than in those with a score of 1 (p<0.017). After removing tongue coating, acetaldehyde concentration decreased significantly (p<0.05). Acetaldehyde concentration was not correlated with other clinical parameters, presence of ...Continue Reading
References
Oct 1, 1986·Alcoholism, Clinical and Experimental Research·H MiyakawaC S Lieber
Jan 1, 1972·Journal of Periodontology·T J O'LearyJ E Naylor
Aug 1, 1984·European Journal of Clinical Investigation·L StavenowH Ohlin
Aug 1, 1995·Journal of Periodontology·H MiyazakiT Takehara
May 1, 1996·Alcohol·Y J DongS J Yin
Nov 5, 1997·Carcinogenesis·N HomannM Salaspuro
Sep 30, 1999·The Tohoku Journal of Experimental Medicine·S TsutayaM Yasujima
Apr 7, 2000·Carcinogenesis·N HomannM Salaspuro
May 21, 2003·Critical Reviews in Clinical Laboratory Sciences·Mikko P Salaspuro
Sep 27, 2003·Clinical Oral Investigations·S RoldánM Sanz
Jan 1, 2005·Biosensors & Bioelectronics·Kohji MitsubayashiYusuke Nakanishi
Jun 30, 2006·Journal of Periodontology·Takatoshi MurataHideo Miyazaki
Jul 25, 2006·Oral Oncology·Johanna KurkivuoriMikko Salaspuro
Oct 31, 2006·Carcinogenesis·Takahiro AsakageHiroshi Watanabe
Jun 27, 2007·Novartis Foundation Symposium·C J Peter Eriksson
Sep 30, 2008·Acta Odontologica Scandinavica·Jukka H Meurman, Johanna Uittamo
May 29, 2009·Archives of Oral Biology·Lena Ernstgård
Jan 25, 2011·Head & Neck·Fumihito SatoKeitaro Matsuo
Jan 1, 2010·The Libyan Journal of Medicine·Sayyada Ghufrana NadeemShahana Urooj Kazmi
Sep 24, 2011·Alcohol·Chien-Ping ChiangShih-Jiun Yin
Aug 23, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M L Gainza-CirauquiR Rautemaa
Mar 1, 2013·Molecular Oral Microbiology·E MarttilaR Rautemaa
Apr 27, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Emilia MarttilaRiina Rautemaa
Sep 24, 2013·PloS One·Andreas HelminenMikko Salaspuro
Dec 21, 2013·BMC Public Health·Min-Ju KimMyeong-Chan Cho
Citations
Mar 17, 2016·BioMed Research International·Kiyoshi TomiyamaToshio Teranaka
Feb 22, 2018·Scientific Reports·Susana I C J PalmaAna C A Roque
Aug 26, 2018·Alcoholism, Clinical and Experimental Research·Ayako Himemiya-HakuchoTatsuya Fujimiya
Apr 28, 2018·Chinese Journal of Integrative Medicine·Su-Ryun Kim, Dong-Hyun Nam
Apr 4, 2019·Esophagus : Official Journal of the Japan Esophageal Society·Aya YokoiManabu Morita
Jun 20, 2019·Journal of Applied Oral Science : Revista FOB·Aya YokoiManabu Morita
Jul 15, 2020·Genome Research·Arnoud BootSteven G Rozen
Mar 25, 2017·Disease Markers·Daisuke EkuniManabu Morita
Oct 31, 2018·Trials·Marcela Leticia Leal GonçalvesSandra Kalil Bussadori
May 20, 2021·PloS One·Fumisato SasakiAkio Ido