Relationship between acid reflux episodes and gastroesophageal reflux symptoms is very inconstant

Digestive Diseases and Sciences
E Colas-AtgerJ Fournet

Abstract

In this prospective study 244 consecutive patients presenting with typical and chronic signs of gastroesophageal reflux were included. Conventional 24-hr esophageal pH monitoring was carried out to establish the symptom association probability, the concordance index, and the symptom sensitivity index. The symptom association probability could be calculated in 110 patients (45%). Two groups were identified: group 1 had normal duration of esophageal acid exposure; subgroup la (nonsignificant symptom association probability) included 39 patients (35.5%) and subgroup lb (significant symptom association probability) included 24 patients (21.8%); group 2 had abnormal duration of esophageal acid exposure; subgroup 2a (nonsignificant symptom association probability) included 21 patients (19.1%) and subgroup 2b (significant symptom association probability) included 26 patients (23.6%). In all, 56.6% of the patients presented typical symptoms of reflux not directly determined by one or repeated acid reflux episodes. The correlation between symptom association probability and the symptom sensitivity index allows for more accurate determination of esophageal acid sensitivity (subgroups lb and 2b).

Citations

Aug 19, 2004·European Journal of Gastroenterology & Hepatology·Daniel Sifrim
Jun 14, 2005·Alimentary Pharmacology & Therapeutics·G L ShihD C Metz
Jun 3, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P G DinningI J Cook
Jan 16, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P G DinningI J Cook
May 2, 2020·The American Journal of Gastroenterology·Kelly ShepherdPeter Eastwood
Jun 27, 2007·Alimentary Pharmacology & Therapeutics·G E E Boeckxstaens
Feb 9, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P W WeijenborgA J Bredenoord
Oct 16, 2004·World Journal of Gastroenterology : WJG·Jin-Hai WangAi-Li Zuo
Oct 15, 2009·Journal of Clinical Gastroenterology·Michael J HershC Prakash Gyawali
Jan 13, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kevin ChanGail Darling

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