Abstract
We biopsied the bronchial mucosa of 20 atopic bronchial asthma patients and measured their serum eosinophil cationic protein (ECP) levels as a means of assessing whether serum ECP could be as a marker of airway eosinophil inflammation. We also investigated the relationship between serum ECP levels and airway hypersensitivity, pulmonary function, peak expiratory flow (PEF) and attack scores. EG2 monoclonal antibody was used to immunostain bronchial mucosal tissue, and positive cells were expressed as the number of positive cells per square millimeter of lamina propria mucosae. A significant correlation was found between bronchial mucosa EG2+ cell counts and serum ECP levels (r = 0.66, p < 0.01), but no clear relationships were detected between serum ECP levels and airway hypersensitivity, pulmonary function, PEF or attack scores. Based on the above findings, serum ECP levels reflect airway eosinophilic inflammation, but ECP levels must be considered in combination with other parameters in relation to the pathophysiology of asthma.
Citations
Feb 17, 2001·Pediatric Pulmonology·R B Tang, S J Chen
Apr 6, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M FujitakaY Abe
May 17, 2000·Current Opinion in Pulmonary Medicine·A Niimi, H Matsumoto
Oct 10, 2001·Chest·A EmelyanovP J Barnes
Aug 24, 1999·Chest·W GruberM S Zach
Jan 13, 2009·Allergy·L P NielsenR Dahl
Dec 26, 2006·Acta Paediatrica·E Berggren BroströmB Winbladh
May 18, 2004·The American Journal of Medicine·Akio NiimiMichiaki Mishima
Feb 19, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yong Ju LeeKyu Earn Kim
Oct 13, 2006·Respiratory Medicine·Gerald C-H KohDavid S-Q Koh
Sep 4, 2001·Respiratory Medicine·B SchmekelP Venge
Apr 16, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J C Kips, R A Pauwels
Dec 22, 1999·The American Journal of Gastroenterology·S C BischoffM P Manns
Oct 3, 1999·Allergy·L PerfettiG Moscato
May 11, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A PatelisA Malinovschi
Jun 27, 2019·Indoor Air·Zuraimi SultanKwok Wai Tham
Jan 27, 2019·The Annals of Otology, Rhinology, and Laryngology·Motohiko SuzukiYoshihisa Nakamura
Jun 17, 2003·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ying-Chu LinHuey-Jen Su
Nov 30, 2020·The Clinical Respiratory Journal·Tuba Erdogan