Relationship between adenosine and T-helper 1/T-helper 2 balance in hyperemesis gravidarum

Clinica Chimica Acta; International Journal of Clinical Chemistry
Yasuko Kiyokawa, Yoshio Yoneyama

Abstract

Adenosine modulates the T-helper (Th) 1/T-helper (Th) 2 balance. We evaluated the relationship between changes in plasma adenosine and the T-helper (Th) 1/T-helper (Th) 2 balance in hyperemesis gravidarum. Plasma adenosine concentrations and the Th1/Th2 ratio were examined in the peripheral blood of 24 women with hyperemesis gravidarum and normal pregnancies. The proportion of CD4-positive cells that expressed intracellular cytokines (interferon gamma and interleukin 4) was analyzed by flow cytometry. The ratio of interferon-gamma-secreting cells to interleukin-4-secreting cells was taken as the Th1/Th2 ratio in vivo. The change induced by adenosine-receptor blocker 8-sulfophenyltheophylline was also measured in vitro to evaluate the possible role of adenosine in modifying the Th1/Th2 balance. In hyperemesis gravidarum, plasma adenosine and the proportion of interleukin-4-secreting cells were increased significantly, and the Th1/Th2 ratio was significantly lower than in normal pregnancy (p<0.05). The decrease in the proportion of IL-4-secreting cells after adenosine receptor blockade in hyperemesis gravidarum significantly exceeded that of normal pregnancy (p<0.05). Increased plasma adenosine may be involved in regulating the T...Continue Reading

References

Nov 1, 1992·The Journal of Clinical Endocrinology and Metabolism·T M GoodwinJ M Hershman
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T J Novak, E V Rothenberg
Jun 28, 1995·JAMA : the Journal of the American Medical Association·J A HillD J Anderson
Jan 1, 1996·Immunologic Research·M P Piccinni, S Romagnani
Dec 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A BashiriM Katz
Jan 16, 1998·International Archives of Allergy and Immunology·Y TohdaS Nakajima
May 20, 1998·Biochemical and Biophysical Research Communications·G ReinhardA V Ruecker
Jun 18, 1998·Annals of the New York Academy of Sciences·R L Wilder
Jul 23, 1999·Annals of the New York Academy of Sciences·M Ostensen
Oct 6, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D Darmochwal-KolarzJ Oleszczuk
Aug 5, 2000·Journal of Reproductive Immunology·S Saito
Dec 26, 2002·American Journal of Obstetrics and Gynecology·Yoshio YoneyamaTsutomu Araki
Nov 8, 2003·Archives of Gynecology and Obstetrics·Naci K KuscuBekir S Uyanik
Mar 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yoshio YoneyamaTsutomu Araki

❮ Previous
Next ❯

Citations

Sep 15, 2015·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·E H BiberogluK Biberoglu
Jan 24, 2007·American Journal of Obstetrics and Gynecology·Norbert Gleicher
Jun 5, 2019·Journal of Laboratory Physicians·Ersin ÇintesunÇetin Çelik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Jennifer R Niebyl
Human Reproduction Update
M F G VerbergJ G Grudzinskas
American Journal of Reproductive Immunology : AJRI
Joanne Kwak-KimAlice Gilman-Sachs
Obstetrics and Gynecology
Adam J WolfbergEllice S Lieberman
© 2022 Meta ULC. All rights reserved