PMID: 16538006Mar 16, 2006Paper

Relationship between adhesion molecules with hs-CRP and changes therein after ARB (Valsartan) administration in patients with obstructive sleep apnea syndrome

The Journal of Medical Investigation : JMI
Norihito KageyamaSusumu Ito

Abstract

It has been reported that a relationship exists between obstructive sleep apnea syndrome (OSAS) and cardiovascular and cerebrovascular diseases. To address this issue, we evaluated whether OSAS is associated with adhesion molecules and inflammatory signs, important indicators of atherosclerosis. Levels of high-sensitivity CRP (hs-CRP) and intercellular adhesion molecule-1 (ICAM-1) were measured in 30 patients with ischemic heart disease, confirmed by coronary arteriography (IHD group). Twenty healthy volunteers without sleep apnea were used as controls (Group N). Sleeping respiratory information was collected using a portable sleep polygraph, together on information about oronasal flow, tracheal sound, chest respiration, and percutaneous oxygen saturation (SpO2) to obtain the apnea-hypopnea index (AHI). In the IHD group, 9 (30%) of the 30 patients showed evidence of OSAS [IHD(AHI> or = 40) group] and 21 did not [IHD(AHI<40) group]. The levels of hs-CRP and ICAM-1 were significantly higher in the IHD group than in the N group (p<0.01). Moreover, the levels of hs-CRP and ICAM-1 were significantly higher in the IHD(AHI > or = 40) group than in the IHD(AHI<40) group (p<0.01). However, after the administration of valsartan, angioten...Continue Reading

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Citations

Feb 13, 2013·Neurotoxicity Research·Mak Adam Daulatzai
Nov 3, 2007·American Journal of Respiratory and Critical Care Medicine·David Gozal, Leila Kheirandish-Gozal
Nov 15, 2011·American Journal of Respiratory and Critical Care Medicine·Jinkwan KimDavid Gozal
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May 17, 2011·Respiratory Physiology & Neurobiology·Jinkwan KimDavid Gozal
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Jul 14, 2010·Sleep Medicine·Leila Kheirandish-GozalDavid Gozal
May 25, 2012·Journal of Minimal Access Surgery·Theodoros E PavlidisAthanasios K Sakantamis

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