Abstract
It has been reported that a relationship exists between obstructive sleep apnea syndrome (OSAS) and cardiovascular and cerebrovascular diseases. To address this issue, we evaluated whether OSAS is associated with adhesion molecules and inflammatory signs, important indicators of atherosclerosis. Levels of high-sensitivity CRP (hs-CRP) and intercellular adhesion molecule-1 (ICAM-1) were measured in 30 patients with ischemic heart disease, confirmed by coronary arteriography (IHD group). Twenty healthy volunteers without sleep apnea were used as controls (Group N). Sleeping respiratory information was collected using a portable sleep polygraph, together on information about oronasal flow, tracheal sound, chest respiration, and percutaneous oxygen saturation (SpO2) to obtain the apnea-hypopnea index (AHI). In the IHD group, 9 (30%) of the 30 patients showed evidence of OSAS [IHD(AHI> or = 40) group] and 21 did not [IHD(AHI<40) group]. The levels of hs-CRP and ICAM-1 were significantly higher in the IHD group than in the N group (p<0.01). Moreover, the levels of hs-CRP and ICAM-1 were significantly higher in the IHD(AHI > or = 40) group than in the IHD(AHI<40) group (p<0.01). However, after the administration of valsartan, angioten...Continue Reading
References
Feb 18, 1998·Annals of Epidemiology·K J GreenlundG S Berenson
Feb 4, 1999·Hypertension·E M MervaalaF C Luft
Jun 22, 2000·Coronary Artery Disease·H SeegerT H Lippert
Nov 7, 2000·The American Journal of Medicine·K ChinM Ohi
Feb 28, 2001·Obesity Research·L RoytblatS Gelman
Mar 7, 2001·Hypertension·Z J ChengE M Mervaala
Sep 19, 2001·Circulation·S BlankenbergJ Meyer
Nov 22, 2001·JAMA : the Journal of the American Medical Association·E LindmarkA Siegbahn
Nov 28, 2001·Circulation·L WuM Horiuchi
Mar 5, 2002·American Journal of Respiratory and Critical Care Medicine·Mary S M IpKaren S L Lam
May 15, 2002·Chest·Ali A El-SolhBrydon J B Grant
May 30, 2002·Circulation·Abu S M ShamsuzzamanVirend K Somers
Mar 5, 2003·Circulation·Takuya YokoeMitsuru Adachi
Mar 26, 2003·Hypertension·Burkhard HornigHelmut Drexler
Jan 21, 2004·Respiration; International Review of Thoracic Diseases·Umur Hatipoğlu, Israel Rubinstein
Feb 12, 2004·Respiration; International Review of Thoracic Diseases·S ImagawaT Nagasawa
Apr 29, 2004·European Journal of Clinical Nutrition·C KoebnickH J F Zunft
Jul 17, 2004·Pneumologie·H Hein
Aug 11, 2004·Mayo Clinic Proceedings·James M Parish, Virend K Somers
Sep 24, 2004·Cytokine·Tansu Ulukavak CiftciAyse Bilgihan
Jan 4, 2005·Respiration; International Review of Thoracic Diseases·I A HarschT Lohmann
Feb 3, 2005·Sleep·Christian GuilleminaultMaurice M Ohayon
Aug 27, 2005·American Journal of Respiratory and Critical Care Medicine·Kenji MinoguchiMitsuru Adachi
Sep 15, 2005·Internal Medicine·Tsuneto AkashibaTakashi Horie
Oct 18, 2005·Journal of Applied Physiology·Naresh M Punjabi, Vsevolod Y Polotsky
Citations
Feb 13, 2013·Neurotoxicity Research·Mak Adam Daulatzai
Jul 15, 2011·Rheumatology·Lukasz KozeraAnn W Morgan
Nov 3, 2007·American Journal of Respiratory and Critical Care Medicine·David Gozal, Leila Kheirandish-Gozal
Nov 15, 2011·American Journal of Respiratory and Critical Care Medicine·Jinkwan KimDavid Gozal
Dec 12, 2007·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hiroshi BandoToru Yokoi
Oct 24, 2008·Archives of Physiology and Biochemistry·Alexandros N Vgontzas
Jan 12, 2008·Chest·Leila Kheirandish-GozalDavid Gozal
Jul 25, 2007·Chest·Naresh M PunjabiNeal Fedarko
May 17, 2011·Respiratory Physiology & Neurobiology·Jinkwan KimDavid Gozal
Dec 17, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Giovanna E CarpagnanoMaria P Foschino Barbaro
Mar 3, 2009·Progress in Cardiovascular Diseases·Rakesh BhattacharjeeDavid Gozal
Jun 3, 2008·Sleep Medicine Clinics·G TrakadaA Vgontzas
May 25, 2012·Acta Oto-laryngologica·Chang Myeon SongJeong-Whun Kim
Jul 14, 2010·Sleep Medicine·Leila Kheirandish-GozalDavid Gozal
Sep 30, 2016·PloS One·Jinkwan KimChol Shin
Feb 17, 2017·Medicine·Jinkwan KimChol Shin
Jan 21, 2010·Journal of Hypertension·Costas TsioufisChristodoulos Stefanadis
May 25, 2012·Journal of Minimal Access Surgery·Theodoros E PavlidisAthanasios K Sakantamis
Nov 9, 2019·Journal of cardiology·Erisa Kawada-WatanabeNobuhisa Hagiwara