Relationship between albuminuric CKD and diabetic retinopathy in a real-world setting of type 2 diabetes: Findings from No blind study

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Ferdinando Carlo SassoNO BLIND Study Group

Abstract

Recently, the albuminocentric view of diabetic kidney disease (DKD) in type 2 diabetes (T2DM) has been changing. Therefore, the relationship between diabetic retinopathy (DR) and chronic kidney disease (CKD) has to be addressed according to this new clinical presentation of DKD. The aim of this study was to evaluate, in a real-world setting, the correlation DR-DKD in T2DM. A total of 2068 type 2 diabetic patients enrolled in a multicenter cross-sectional study were investigated. Albuminuric subjects were largely prevalent among subjects with DR (p = 0.019). In the whole study population, no difference in albumin excretion rate (AER) was observed between presence/absence of DR; instead, AER was significantly higher among patients with glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 (CKD) (p = 0.009), above all in those with CKD and AER ≥0.03 g/24 h (p = 0.005). Multivariate analysis confirmed that eGFR (O.R. 0.976; 95% C.I.: 0.960-1.028; p < 0.001) and AER (O.R. 1.249; 95% C.I. 1.001-1.619; p = 0.004) were independently associated with DR and HDL-cholesterol (O.R.: 1.042; 95% C.I.: 1.011-1.120; p = 0.014). Additionally, among patients with eGFR <60 mL/min/1.73 m2 and albuminuria, both eGFR and AER significantly varied betw...Continue Reading

Citations

Dec 31, 2020·Journal of Clinical Medicine·Shi-Chue HsingWen-Hui Fang
Mar 7, 2021·Diagnostics·Pia Clara PafundiFerdinando Carlo Sasso
Jul 23, 2021·Clinical Interventions in Aging·Sameer P LeleyAshay D Bhatwadekar
Jul 20, 2021·Diabetes Research and Clinical Practice·Alfredo CaturanoFerdinando Carlo Sasso
Dec 7, 2021·International Journal of Retina and Vitreous·Monica Oliveira da SilvaDaniel Lavinsky

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